RESEARCH PUBLICATIONS, PATENTS, AND BOOK CHAPTERS

 

Eric N. Jacobsen

 

1.          Wenke, G.; Jacobsen, E. N.; Totten, G. E.; Karydas, A. C.; Rhodes, Y. E. “Silyl Ketene Acetal Chemistry: Steric Limitations in Lewis Acid-Promoted Addition of Ketones,” Synth. Commun. 1983, 13, 449.

 

2.          Jacobsen, E. N.; Bergman, R. G. “Synthesis, Crystal and Molecular Structure, and Reactions of the Bridging Vinylidenedicobalt Complex (µ-CCH₂)(CpCoCO)₂.  Reaction with Molybdenum Hydrides to Give a Heteronuclear Cluster Complex,” Organometallics 1984, 3, 329.

 

3.          Jacobsen, E. N.; Totten, G. E.; Wenke, G.; Karydas, A. C.; Rhodes, Y. E. “Steric Effects on the Titanium Tetrachloride-Promoted Dimerization of Silyl Ketene Acetals,” Synth. Commun. 1985, 15, 301.

 

4.          Jacobsen, E. N.; Bergman, R. G. “Synthesis and Chemistry of a Bridging Vinylidenedicobalt Complex.  Evidence for a Non-Chain Radical Mechanism in its Reaction with Metal Hydrides to Give Heteronuclear Clusters,” J. Am. Chem. Soc. 1985, 107, 2023.

 

5.          Jacobsen, E. N.; Trost, M. K.; Bergman, R. G. “Synthesis of Organometallic Heterodinuclear µ-Oxo Complexes by Extrusion of Alkenes from Zirconium/Tungsten Oxaalkyl Complexes,” J. Am. Chem. Soc. 1986, 108, 8092.

 

6.          Jacobsen, E. N.; Markó, I. E.; Mungall, W. S.; Schröder, G. W.; Sharpless, K. B. “Asymmetric Dihydroxylation via Ligand-Accelerated Catalysis,” J. Am. Chem. Soc. 1988, 110, 1968.

 

7.          Jacobsen, E. N.; Goldberg, K. I.; Bergman, R. G. “Rapid, Reversible Intramolecular C-H Oxidative Addition and H-Exchange in a Heterodinuclear 'Early-Late' Transition Metal Complex,” J. Am. Chem. Soc. 1988, 110, 3706.

 

8.          Jacobsen, E. N.; Markó, I. E.; France, M. B.; Svendsen, J. S.; Sharpless, K. B. “Kinetic Role of Alkaloid Ligands in Asymmetric Catalytic Dihydroxylation,” J. Am. Chem. Soc. 1989, 111, 737.

 

9.          Wai, J. S. M.; Markó, I. E.; Svendsen, J. S.; Finn, M. G.; Jacobsen, E. N.; Sharpless, K. B. “A Mechanistic Insight Leads to a Greatly Improved Osmium-Catalyzed Asymmetric Dihydroxylation Process,” J. Am. Chem. Soc. 1989, 111, 1123.

 

10.      Svendsen, J. S.; Markó, I. E.; Jacobsen, E. N.; Pulla Rao, Ch.; Bott, S.; Sharpless, K. B. “On the Structure of Osmium Tetroxide-Cinchona Alkaloid Complexes,” J. Org. Chem. 1989, 54, 2263.

 

 

11.      Zhang, W.; Loebach, J. L.; Wilson, S. R.; Jacobsen, E. N. “Enantioselective Epoxidation of Unfunctionalized Olefins Catalyzed by (salen)Manganese Complexes,” J. Am. Chem. Soc. 1990, 112, 2801–2803.

 

12.      Zhang, W.; Jacobsen, E. N. “Preparation of trans-1,2-Diamino-1,2-Dimethylcyclohexane via Highly Stereoselective Olefin Oxidation by Dinitrogen Tetroxide,” Tetrahedron Lett. 1991, 32, 1711–1714.

 

13.      Zhang, W.; Jacobsen, E. N. “Asymmetric Epoxidation with Sodium Hypochlorite Catalyzed by Readily Available Chiral Mn(III) Salen Complexes,” J. Org. Chem. 1991, 56, 2296–2298.

 

14.      Jacobsen, E. N.; Zhang, W.; Muci, A. R.; Ecker, J. R.; Deng, L. “Highly Enantioselective Epoxidation Catalysts Derived from 1,2-Diaminocyclohexane,” J. Am. Chem. Soc. 1991, 113, 7063–7064.

 

15.      Fu, H.; Look, G. C.; Zhang, W.; Jacobsen, E. N.; Wong, C.-H. “Mechanistic Study of a Synthetically Useful Mono-oxygenase Model Using Hypersensitive Probes cis and trans-2-phenyl-1-Vinylcyclopropane,” J. Org. Chem. 1991, 56, 6497–6500.

 

16.      Jacobsen, E. N.; Güler, M. L.; Zhang, W. “Electronic Tuning of Asymmetric Catalysts,” J. Am. Chem. Soc. 1991, 113, 6703–6704.

 

17.      Jacobsen, E. N. “Asymmetric Synthesis,” in 1992 Yearbook of Science & Technology, McGraw-Hill, Inc., New York; 1991, p. 34.

 

18.      Lee, N. H.; Muci, A. R.; Jacobsen, E. N. “Enantiomerically Pure Epoxychromans via Asymmetric Catalysis,” Tetrahedron Lett. 1991, 32, 5055–5058.

 

19.      Lee, N. H.; Jacobsen, E. N. “Enantioselective Epoxidation of Conjugated Dienes and Enynes.  Trans-Epoxides from Cis-Olefins,” Tetrahedron Lett. 1991, 32, 6533–6536.

 

20.      Deng, L.; Jacobsen, E. N.  “A Practical, Highly Enantioselective Synthesis of the Taxol Side Chain via Asymmetric Catalysis,” J. Org. Chem. 1992, 57, 4320–4323.

 

21.      Pospisil, P. J.; Jacobsen, E. N.  “A Substoichiometric Pyridine•Lithium Enolate Complex: Solution and X-Ray Data, and Implications to Catalysis in the Aldol Reaction,” J. Am. Chem. Soc. 1992, 114, 7585–7587.

 

22.      Palucki, M.; Hanson, P.; Jacobsen, E. N.  “Asymmetric Oxidation of Sulfides with H₂O₂ Catalyzed by (salen)Mn(III) Complexes,” Tetrahedron Lett. 1992, 33, 7111–7114.

 

23.      Baudry, M.; Etienne, S.; Bruce, A.; Palucki, M.; Jacobsen, E.; Malfroy, B. “Salen-Manganese Complexes are Superoxide Dismutate Mimics,” Biochem. Biophys. Res. Commun. 1993, 192, 964–968.

 

24.      Li, Z.; Conser, K. R.; Jacobsen, E. N.  “Asymmetric Alkene Aziridination with Readily Available Chiral Diimine-Based Catalysts,” J. Am. Chem. Soc. 1993, 115, 5326–5327.

 

25.      Allain, E. A.; Hager, L. P.; Deng, L.; Jacobsen, E. N. “Highly Enantioselective Epoxidation of Disubstituted Alkenes with Hydrogen Peroxide Catalyzed by Chloroperoxidase,” J. Am. Chem. Soc. 1993, 115, 4415–4416.

 

26.      Heinze, K. F.; Allen, J. L.; Jacobsen, E. N. “Encouraging Tomorrow's Chemists: University Outreach Program Bringing Hands-On Experiments to Local Students,” J. Chem. Educ. 1995, 72, 167–169.

 

27.      Jacobsen, E. N. “Asymmetric Catalytic Epoxidation of Unfunctionalized Olefins,” in Catalytic Asymmetric Synthesis, Ojima, I., Ed.; VCH: New York, 1993; Chapter 4.2. 

 

28.      Fields, L. B.; Jacobsen, E. N. “Synthesis and Characterization of Chiral Bimetallic Complexes Bearing Hard and Soft Lewis Acidic Sites,” Tetrahedron: Asymmetry 1993, 4, 2229–2240.

 

29.      Chang, S.; Lee, N. H.; Jacobsen, E. N. “Regio- and Enantioselective Epoxidation of Conjugated Polyenes.  Formal Synthesis of LTA₄ Methyl Ester,” J. Org. Chem. 1993, 58, 6939–6941.

 

30.      Zhang, W.; Lee, N. H.; Jacobsen, E. N. “Non-Stereospecific Mechanisms in Asymmetric Addition to Alkenes Result in Enantiodifferentiation after the First Irreversible Step,” J. Am. Chem. Soc. 1994, 116, 425–426.

 

31.      Jacobsen, E. N.; Deng, L.; Furukawa, Y.; Martínez, L. E. “Enantioselective Catalytic Epoxidation of Cinnamate Esters,” Tetrahedron  1994, 50, 4323–4334.

 

32.      Chang, S.; Heid, R. M.; Jacobsen, E. N. “Enantioselective Epoxidation of Cyclic 1,3-Dienes Catalyzed by a Sterically and Electronically Optimized (Salen)Mn Complex,” Tetrahedron Lett. 1994, 35, 669–672.

 

33.      Larrow, J. F.; Jacobsen, E. N.; Gao, Y.; Hong, Y.; Nie, X.; Zepp, C. M. “A Practical Process for the Large-Scale Preparation of (R,R)-N,N’-Bis(3,5-Di-tert-butylsalicylidene)-1,2-Cyclohexanediaminomanganese (III) Chloride, a Highly Enantioselective Epoxidation Catalyst,” J. Org. Chem. 1994, 59, 1939–1940.

 

34.      Chang, S.; Galvin, J. M.; Jacobsen, E. N. “Effect of Chiral Quaternary Ammonium Salts on (salen)Mn-Catalyzed Epoxidation of cis-Olefins.  A Highly Enantioselective, Catalytic Route to Trans Epoxides,” J. Am. Chem. Soc. 1994, 116, 6937–6938.

 

35.      Brandes, B. D.; Jacobsen, E. N. “Highly Enantioselective, Catalytic Epoxidation of Trisubstituted Olefins,” J. Org. Chem. 1994, 59, 4378–4380.

 

36.      Palucki, M.; Pospisil, P. J.; Zhang, W.; Jacobsen, E. N. “Highly Enantioselective, Low Temperature Epoxidation of Terminal Olefins,” J. Am. Chem. Soc. 1994, 116, 9333–9334.

 

37.      Larrow, J. F.; Jacobsen, E. N. “Kinetic Resolution of 1,2-Dihydronaphthalene Oxide and Related Epoxides via Asymmetric C–H Hydroxylation,” J. Am. Chem. Soc. 1994, 116, 12129–12130.

 

38.      Jacobsen, E. N.; Finney, N. S. “Synthetic and Biological Catalysts for Chemical Synthesis: How to Assess Practical Utility,” Chem.  Biol. 1994, 1, 85–90.

 

39.      Hansen, K. H.; Finney, N. S.; Jacobsen, E. N. “Carbenoid Transfer to Imines: A New Asymmetric Catalytic Synthesis of Aziridines,” Angew. Chem. Int. Ed. Engl. 1995, 34, 676–678.

 

40.      Jacobsen, E. N.; Galvin, J. M. “Sodium Hypochlorite,” in Encyclopedia of Reagents for Organic Synthesis, Volume 7, Paquette, L.A., Ed.; Wiley: New York, 1995,  pp. 4580–4585.

 

41.      Jacobsen, E. N. “Sodium Hypochlorite-Chiral Manganese (III) Salen Complexes,” in Encyclopedia of Reagents for Organic Synthesis, Volume 7, Paquette, L.A., Ed.; Wiley: New York, 1995, pp. 4585–4586.

 

42.      Martínez, L. E.; Leighton, J. L.; Carsten, D. H.; Jacobsen, E. N. “Highly Enantioselective Ring Opening of Epoxides Catalyzed by Chiral (salen)Cr(III) Complexes,” J. Am. Chem. Soc. 1995, 117, 5897–5898.

 

43.      Li, Z.; Quan, R. W.; Jacobsen, E. N. “Mechanistic Study of the (diimine)Cu-Catalyzed Asymmetric Azridination of Alkenes.  Nitrene Transfer via Ligand-Accelerated Catalysis,” J. Am. Chem. Soc. 1995, 117, 5889–5890.

 

44.      Jacobsen, E. N. “Transition Metal Catalyzed Oxidations: Asymmetric Epoxidation ,” in Comprehensive Organometallic Chemistry II, Vol. 12, Wilkinson, G.; Stone, F. G. A.; Abel, E. W.; Hegedus, L. S., Eds.; Pergamon: New York; 1995, pp. 1097–1135.

 

45.      Jacobsen, E. N. “Fundamental and Applied Studies in Asymmetric Oxidation Catalysis,” in Stereoselective Reactions of Metal-Activated Molecules, Werner, H. and Sundmeyer, J., Eds.; Vieweg: New York; 1995, pp. 17–26.

 

46.      Brandes, B. D.; Jacobsen, E. N. “Enantioselective Catalytic Epoxidation of Tetrasubstituted Olefins,” Tetrahedron Lett. 1995, 36, 5123–5126.

 

47.      Palucki, M.; McCormick, G. J.; Jacobsen, E. N. “Low Temperature Asymmetric Epoxidation of Unfunctionalized Olefins Catalyzed by (salen)Mn(III) Complexes,” Tetrahedron Lett. 1995, 36, 5457–5460.

 

48.      Vander Velde, S. L.; Jacobsen, E. N. “Kinetic Resolution of Racemic Chromenes via Asymmetric Epoxidation; Synthesis of (+)-Teretifolione B,” J. Org. Chem. 1995, 60, 5380–5381.

 

49.      Leighton, J.L.; Jacobsen, E.N. “Efficient Synthesis of (R)-4-Trimethylsilyloxy-2- cyclopentenone by Enantioselective Catalytic Epoxide Ring Opening,” J. Org.Chem. 1996, 61, 389–390.

 

50.      Larrow, J.F.; Schaus, S.E.; Jacobsen, E.N. “Kinetic Resolution of Terminal Epoxides via Highly Regioselective and Enantioselective Ring Opening with TMSN₃. An Efficient, Catalytic Route to 1,2-Aminoalcohols,” J. Am. Chem. Soc. 1996, 118, 7420–7421.

 

51.      Pospisil, P.J.; Carsten, D.H.; Jacobsen, E.N. “X-Ray Structural Studies of Highly Enantioselective Mn(salen) Epoxidation Catalysts,” Chem. Eur. J. 1996, 2, 974–980.

 

52.      Quan, R.W.; Li, Z.; Jacobsen, E.N. “Enantioselective Binding of Prochiral Olefins to a Chiral Catalyst via Simultaneous Face-Face and Edge-Face Aromatic Interactions,” J. Am. Chem. Soc. 1996, 118, 8156–8157.

 

53.      Francis, M.B.; Finney, N.S.; Jacobsen, E.N. “Combinatorial Approach to the Discovery of Novel Coordination Compounds," J. Am. Chem. Soc. 1996, 118, 8983–8984.

 

54.      Martinez, L.E.; Nugent, W.A.; Jacobsen, E.N. “Highly Efficient and Enantioselective Synthesis of Carbocyclic Nucleoside Analogs Using Selective Early Transition Metal Catalysis,” J. Org. Chem. 1996, 61, 7963–7966.

 

55.      Schaus, S.E.; Jacobsen, E.N. “Dynamic Kinetic Resolution of Epichlorohydrin via Enantioselective Catalytic Ring Opening with TMSN₃. Practical Synthesis of Aryl Oxazolidinone Antibacterial Agents,” Tetrahedron Lett. 1996, 37, 7939–7942.

 

56.      Hansen, K.B.; Leighton, J.L.; Jacobsen, E.N. “On the Mechanism of Asymmetric Nucleophilic Ring-Opening of Epoxides Catalyzed by (Salen)Cr(III) Complexes,” J. Am. Chem. Soc. 1996, 118, 10924–10925.

 

57.      Jacobsen, E.N.; Kakiuchi, F.; Konsler, R.G.; Larrow, J.F.; Tokunaga, M. “Enantioselective Catalytic Ring Opening of Epoxides with Carboxylic Acids,” Tetrahedron Lett. 1997, 38, 773–776.

 

58.      Wu, M.H.; Jacobsen, E.N. “An Efficient Formal Synthesis of Balanol via the Asymmetric Epoxide Ring Opening Reaction,” Tetrahedron Lett. 1997, 38, 1693–1696.

 

59.      Schaus, S.E.; Larrow, J.F.; Jacobsen, E.N. “Practical Synthesis of Enantiopure Cyclic 1,2-Aminoalcohols via Catalytic Asymmetric Ring Opening of Meso Epoxides,” J. Org. Chem. 1997, 62, 4197–4199.

 

60.      Jacobsen, E.N.; Zhang, W.; Deng, L. “Chiral Catalysts and Epoxidation Reactions Catalyzed Thereby,” U.S. Patent No. 5, 637, 739 issued 6/10/97.

 

61.      Jacobsen, E.N.; Zhang, W.; Deng, L. “Chiral Catalysts and Epoxidation Reactions,” U.S. Patent No. 5, 663, 393 issued 9/2/97.

 

62.      Tokunaga, M.; Larrow, J.F.; Kakiuchi, F.; Jacobsen, E.N. “Asymmetric Catalysis with Water: Efficient Kinetic Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis,” Science 1997, 277, 936–938.

 

63.      Finney, N.S.; Pospisil, P.J.; Chang, S.; Palucki, M.; Hansen, K.B.; Jacobsen, E.N. “On the Viability of Metallaoxetane Intermediates in the (salen)Mn-Catalyzed Asymmetric Epoxidation Reaction,” Angew. Chem. Int. Ed. Engl. 1997, 36, 1720–1723.

 

64.      Jacobsen, E.N.; Martinez, L.E.; Leighton, J.L. “Stereoselective Ring Opening Reactions,” U.S. Patent No. 5, 665, 890 issued 9/9/97.

 

65.      Brandes, B.D.; Jacobsen, E.N. “Synthesis of Enantiopure 3-Chlorostyrene Oxide via an Asymmetric Epoxidation/Hydrolytic Kinetic Resolution Sequence,” Tetrahedron: Asymmetry 1997, 8, 3927–3933.

 

66.      Larrow, J.F.; Jacobsen, E.N. “(R,R)-N,N'-Bis(3,5-Di-tert-butylsalicylidene)-1,2- Cyclohexanediaminomanganese (III) Chloride, a Highly Enantioselective Epoxidation Catalyst,” Organic Synth. 1997, 75, 1–10.

 

67.      Schaus, S.E.; Brånalt, J.E.; Jacobsen, E.N. “Asymmetric Hetero-Diels-Alder Reactions Catalyzed by Chiral (salen)Chromium(III) Complexes,” J. Org. Chem. 1998, 63, 403–405.

 

68.      Palucki, M.; Finney, N.S.; Pospisil, P.J.; Güler, M.L.; Ishida, T.; Jacobsen, E.N. “The Mechanistic Basis for Electronic Effects on Enantioselectivity in the (salen)Mn-Catalyzed Epoxidation Reaction,” J. Am. Chem. Soc. 1998, 120, 948–954.

 

69.      Sigman, M.S.; Jacobsen, E.N. “Schiff Base Catalysts for the Asymmetric Strecker Reaction Identified and Optimized from Parallel Synthetic Libraries,” J. Am. Chem. Soc. 1998, 120, 4901–4902.

 

70.      Sigman, M.S.; Jacobsen, E.N. “Enantioselective Addition of Hydrogen Cyanide to Imines Catalyzed by a Chiral (salen)Al(III) Complex,” J. Am. Chem. Soc. 1998, 120, 5315–5316.

 

71.      Francis, M.B.; Jamison, T.F.; Jacobsen, E.N. “Combinatorial Libraries of Transition Metal Complexes, Catalysts, and Materials,” Curr. Opinion Chem. Biol. 1998, 2, 422–428.

 

72.      Schaus, S.E.; Brånalt, J.E.; Jacobsen, E.N. “Total Synthesis of Muconin by Efficient Assembly of Chiral Building Blocks,” J. Org. Chem. 1998, 63, 4876–4877.

 

73.      Wu, M.H.; Jacobsen, E.N. “Asymmetric Ring Opening of Meso Epoxides with Thiols: Enantiomeric Enrichment Using a Bifunctional Nucleophile,” J. Org. Chem. 1998, 63, 5252–5254.

 

74.      Annis, D.A.; Jacobsen, E.N. “Solid Phase Synthesis of Cyclic RGD Peptide Derivatives via Asymmetric Catalysis: Stereochemistry as a Diversity Element,” Angew. Chem. Int. Ed. 1998, 37, 1907–1909.

 

75.      Furrow, M.E.; Schaus, S.E.; Jacobsen, E.N. “Practical Access to Highly Enantioenriched   C-3 Building Blocks via Hydrolytic Kinetic Resolution,” J. Org. Chem. 1998, 63, 6776–6777.

 

76.      Konsler, R.G.; Karl, J.; Jacobsen, E.N. “Cooperative Asymmetric Catalysis Using Dimeric Salen Complexes,” J. Am. Chem. Soc. 1998, 120, 10780–10781.

 

77.      Dakin, L. A.; Schaus, S.E.; Jacobsen, E.N.; Panek, J.S., “Carbenoid Insertions into the Silicon-Hydrogen Bond Catalyzed by Chiral Copper (I) Schiff Base Complexes,” Tetrahedron Lett. 1998, 39, 8947–8950.

 

78.      Lebel, H.; Jacobsen, E.N. “Enantioselective Total Synthesis of Taurospongin A,” J. Org. Chem. 1998, 63, 9624–9625.

 

79.      Larrow, J.F.; Roberts, E.; Verhoeven, T.R.; Ryan, K.M.; Senanayake, C.H.; Reider, P.J.; Jacobsen, E.N. “(1S,2R)-1-Aminoindan-2-ol,” Organic Synth. 1998, 76, 46–56.

 

80.      Hinterding, K.; Jacobsen, E.N. “Regioselective Carbomethoxylation of Chiral Epoxides: a New Route to Enantiomerically Pure b-Hydroxyesters,” J. Org. Chem. 1999, 64, 2164–2165.

 

81.      Francis, M. B.; Jacobsen, E. N. “Discovery of Novel Catalysts for Alkene Epoxidation Using Metal-Binding Combinatorial Libraries,” Angew. Chem. Int. Ed. 1999, 38, 937–941.

 

82.      Annis, D. A.; Jacobsen, E. N. “Polymer-Supported Chiral Co(Salen) Complexes: Synthetic Applications and Mechanistic Investigations in the Hydrolytic Kinetic Resolution of Terminal Epoxides,” J. Am. Chem. Soc. 1999, 121, 4147–4154.

 

83.      Senanayake, C. H.; Jacobsen, E. N. “Chiral (Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical Synthesis of cis-Aminoindanol and Its Application to Enantiopure Drug Synthesis,” in Process Chemistry in the Pharmaceutical Industry, Gadamasetti, K. G., Ed.; Dekker: New York, 1999, pp. 347–368.

 

84.      Ready, J. M.; Jacobsen, E. N. “Asymmetric Catalytic Synthesis of a-Aryloxy Alcohols: Kinetic Resolution of Terminal Epoxides via Highly Enantioselective Ring Opening with Phenols,” J. Am. Chem. Soc. 1999, 121, 6086–6087.

 

85.      Wu, M. H.; Hansen, K. B.; Jacobsen, E. N. “Regio- and Enantioselective Cyclization of Epoxy Alcohols Catalyzed by a [Co^III(salen)] Complex,” Angew. Chem. Int. Ed. 1999, 38, 2012–2014.

 

86.      Jacobsen, E. N.; Martinez, L. E.; Leighton, J. L. “Stereoselective Ring Opening Reactions,” U.S. Patent No. 5, 929, 232 issued 7/27/99.

 

87.      Dossetter, A. G.; Jamison, T. F.; Jacobsen, E. N. “Highly Enantio- and Diastereoselective Hetero-Diels-Alder Reactions Catalyzed by New Chiral Tridentate Chromium Catalysts,” Angew. Chem. Int. Ed. 1999, 38, 2398–2400.

 

88.      Lebel, H.; Jacobsen, E. N. “Chromium Catalyzed Kinetic Resolution of 2,2-Disubstituted Epoxides,” Tetrahedron Lett. 1999, 40, 7303–7306.

 

89.      Myers, J. K.; Jacobsen, E. N. “Asymmetric Synthesis of b-Amino Acid Derivatives via Catalytic Conjugate Addition of Hydrazoic Acid to Unsaturated Imides,” J. Am. Chem. Soc. 1999, 121, 8959–8960.

 

90.      Jacobsen, E. N.; Wu, M. H. “Epoxidation of Alkenes Other than Allylic Alcohols,” in Comprehensive Asymmetric Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New York; 1999, Chapter 18.2.

 

91.      Jacobsen, E. N.; Wu, M. H. “Ring Opening of Epoxides and Related Reactions,” in Comprehensive Asymmetric Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New York; 1999, Chapter 35.

 

92.      Jacobsen, E. N. “Aziridination,” in Comprehensive Asymmetric Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New York; 1999, Chapter 17.

 

93.      Jacobsen, E. N. “Future Perspectives in Asymmetric Catalysis,” in Comprehensive Asymmetric Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New York; 1999, Chapter 42.

 

94.      Peukert, S.; Jacobsen, E. N. “Enantioselective Parallel Synthesis Using Polymer-Supported Chiral Co(Salen) Complexes,” Org. Lett. 1999, 1, 1245–1248.

 

95.      Li, Z.; Fernandez, M.; Jacobsen, E. N. “Enantioselective Ring-opening of meso Aziridines Catalyzed by Tridentate Schiff-base Chromium(III) Complexes,” Org. Lett. 1999, 1, 1611–1613.

 

96.      Jacobsen, E. N.; Breinbauer, R. “Nickel Comes Full Cycle,” (Perspective) Science 2000, 287, 437.

 

97.      Sigman, M. S.; Vachal, P.; Jacobsen, E. N. “A General Catalyst for the Asymmetric Strecker Reaction,” Angew. Chem. Int. Ed. 2000, 39, 1279–1281.

 

98.      Vachal, P.; Jacobsen, E. N. “Enantioselective Catalytic Addition of HCN to Ketoimines.  Catalytic Synthesis of Quaternary Amino Acids” Org. Lett. 2000, 2, 867–870.

 

99.      Schaus, S. E.; Jacobsen, E. N. “Asymmetric Ring-Opening of Meso-Epoxides with TMSCN Catalyzed by (pybox)Lanthanide Complexes,” Org. Lett. 2000, 2, 1001–1004.

 

100.  Jacobsen, E. N. “Asymmetric Catalysis of Epoxide Ring-Opening Reactions,” Acc. Chem. Res. 2000, 33, 421–431.

 

101.  Breinbauer, R.; Jacobsen, E. N. “Cooperative Asymmetric Catalysis with Dendrimeric Co(salen) Complexes,” Angew. Chem. Int. Ed. 2000, 39, 3604–3607.

102.  Jacobsen, E. N.; Schaus, S. E. "Asymmetric Cycloaddition Reactions," U.S. Patent No. 6,130,340 issued 10/10/00.

 

103.  Thompson, C. F.; Jamison, T. F.; Jacobsen, E. N. “Total Synthesis of FR901464.  Convergent Assembly of Chiral Components Prepared by Asymmetric Catalysis,” J. Am. Chem. Soc. 2000, 122, 10482–10483.

 

104.  Keith, J. M.; Larrow, J. F.; Jacobsen, E. N. “Practical Considerations in Kinetic Resolution Reactions,” Adv. Synth. & Catal. 2001, 343, 5–26.

 

105.  Su, J. T.; Vachal, P.; Jacobsen, E. N. “Practical Synthesis of a Soluble Schiff Base Catalyst for the Asymmetric Strecker Reaction,” Adv. Synth. & Catal. 2001, 343, 197–200.

106.  Ready, J. M.; Jacobsen, E. N. “Highly Active Oligomeric (salen)Co Catalysts for Asymmetric Epoxide Ring Opening Reactions,” J. Am. Chem. Soc. 2001, 123, 2687–2688.

107.  Jacobsen, E. N.; Schaus, S. E.; Dossetter, A. G.; Jamison, T. F. “Asymmetric Cycloaddition Reactions,” U.S. Patent #6,211,370 issued 4/3/01.

108.  Brandes, B. D.; Jacobsen, E. N. “Regioselective Ring Opening of Enantiomerically Enriched Epoxides via Catalysis with Chiral (Salen)Cr(III) Complexes,” Synlett 2001, 1013–1015.

109.  White, M. C.; Doyle, A. G.; Jacobsen, E. N. “Synthetically Useful, Self-Assembling MMO Mimic System for Catalytic Alkene Epoxidation with Aqueous H₂O₂,” J. Am. Chem. Soc. 2001, 123, 7194–7195.

110.  Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F. “Hydrolytic Kinetic Resolution of Cyclic Substrates” U.S. Patent No. 6,262,278 B1 issued 7/17/01.

111.  Chavez, D. E.; Jacobsen, E. N. “Total Synthesis of Fostriecin (CI-920),” Angew. Chem. Int. Ed. 2001, 40, 3667–3670.

112.  Thompson, C. F.; Jamison, T. F.; Jacobsen, E. N. “FR901464: Total Synthesis, Proof of Structure, and Evaluation of Synthetic Analogs,” J. Am. Chem. Soc. 2001, 123, 9974–9983.

113.  Liu, P.; Jacobsen, E. N. “Total Synthesis of (+)-Ambruticin,” J. Am. Chem. Soc. 2001, 123, 10772–10773.

114.  Jacobsen, E. N., Sigman, M. S. “Parallel Combinatorial Approach to the Discovery and Optimization of Catalysts and Uses Thereof,” U.S. Patent #6,316,616, issued 11/13/01

115.  Schaus, S. E.; Brandes, B. D; Larrow, J. F.; Tokunaga, M.; Hansen, K. B.; Gould, A. E.; Furrow, M. E.; Jacobsen, E. N. “Highly Selective Hydrolytic Kinetic Resolution of Terminal Epoxides Catalyzed by Chiral (salen)Cobalt(III)-Complexes.  Practical Synthesis of Enantioenriched Terminal Epoxides and 1,2-Diols,” J. Am. Chem. Soc. 2002, 124, 1307–1315.

116.  Movassaghi, M.; Jacobsen, E. N. “A Direct Method for the Conversion of Terminal Epoxides into g-Butanolides,” J. Am. Chem. Soc. 2002, 124, 2456–2457.

117.  Ruck, R. T.; Jacobsen, E. N. “Asymmetric Catalysis of Hetero-Ene Reactions with Tridentate Schiff Base Chromium(III) Complexes,” J. Am. Chem. Soc. 2002, 124, 2882–2883.

118.  Ready, J. R.; Jacobsen, E. N. “A Practical Oligomeric (salen)Co Catalyst for Asymmetric Epoxide Ring Opening Reactions,” Angew. Chem. Int. Ed. 2002, 41, 1374–1377.

119.  Joly, G. D.; Jacobsen, E. N. “Catalyst-Controlled Diastereoselective Hetero-Diels–Alder Reactions,” Organic Lett. 2002, 4, 1795–1798.

120.  Jacobsen, E. N.; Schaus, S. E.; Dossetter, A. G.; Jamison, T. F. “Asymmetric Cycloaddition Reactions,” U.S. Patent #6,369,223 issued 4/9/02.

121.  Gademann, K.; Chavez, D. E.; Jacobsen, E. N. “Highly Enantioselctive Inverse Electron Demand Hetero-Diels–Alder Reactions of a,b-Unsaturated Aldehydes,” Angew. Chem. Int. Ed. 2002, 41, 3059–3061.

122.  Jacobsen, E. N.; Francis, M. B.; Finney, N. S. "Combinatorial Approach for Generating Novel Coordination Complexes," U.S. Patent #6,489,093 issued 12/3/02.

123.  Vachal, P.; Jacobsen, E. N. “Structure-Based Analysis and Optimization of a Highly Enantioselective Catalyst for the Strecker Reaction,” J. Am. Chem. Soc. 2002, 124, 10012–10014.

124.  Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F. “Hydrolytic Kinetic Resolution of Cyclic Substrates” U.S. Patent # 6,448,414 issued 9/10/02.

125.  Goodman, S. N.; Jacobsen, E. N. “A Practical Synthesis of a,b-Unsaturated Imides, Useful Substrates For Asymmetric Conjugate Addition Reactions,” Adv. Synth. Catal. 2002, 344, 953–956.

126.  Wenzel, A. G.; Jacobsen, E. N. “Asymmetric Catalytic Mannich Reactions Catalyzed by Urea Derivatives: Enantioselective Synthesis of b-Aryl-b-Amino Acids,” J. Am. Chem. Soc. 2002, 124, 12964–12965.

127.  Movassaghi, M.; Jacobsen, E. N. “The Simplest ‘Enzyme’,” (Perspective) Science 2002, 298, 1904–1905.

128.  Goodman, S. N.; Jacobsen, E. N. “Enantiopure b-Hydroxy Morpholine Amides From Terminal Epoxides via Carbonylation at 1 Atm,” Angew. Chem. Int. Ed. 2002, 41, 4703–4705.

129.  Yoon, T. P.; Jacobsen, E. N. “Privileged Chiral Catalysts,” Science 2003, 299, 1691–1693.

130.  Sammis, G. M.; Jacobsen, E. N. “Highly Enantioselective, Catalytic Conjugate Addition of Cyanide to a,b-Unsaturated Imides,” J. Am. Chem. Soc. 2003, 125, 4442–4443.

131.  Jacobsen, E. N., Sigman, M. S. "Main Group Metal-Based Asymmetric Catalysts and Applications Thereof," U.S. Patent #6,521,561 issued 2/18/03.

132.  Chavez, D. E.; Jacobsen, E. N. “Catalyst-Controlled Inverse Electron Demand Hetero-Diels–Alder Reactions in the Enantio- and Diastereoselective Synthesis of Iridoid Natural Products,” Org. Lett. 2003, 5, 2563–2565.

133.  Taylor, M. S.; Jacobsen, E. N. “Enantioselective Michael Additions to a,b-Unsaturated Imides Catalyzed by a Salen-Al Complex,” J. Am. Chem. Soc. 2003, 125, 11204–11205.

134.  Wenzel, A. G.; Lalonde, M. P.; Jacobsen, E. N. “Divergent Stereoinduction Mechanisms in Urea-Catalyzed Additions to Imines,” Synlett 2003, 12, 1919–1922.

135.  Ruck, R. T.; Jacobsen, E. N. “Asymmetric Hetero-Ene Reactions of Trimethylsilyl Enol Ethers Catalyzed by Tridentate Schiff Base Chromium(III) Complexes,” Angew. Chem. Int. Ed. 2003, 42, 4771–4774.

136.  White, D. E.; Jacobsen, E. N. “New Oligomeric Catalyst for the Hydrolytic Kinetic Resolution of Terminal Epoxides Under Solvent-Free Conditions,” Tetrahedron: Asymm. 2003, 14, 3633–3638.

137.  Vachal, P.; Jacobsen, E. N. “Cyanation of Carbonyl and Imino Groups,” in Comprehensive Asymmetric Catalysis (1^st Supplement), Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New York; 2003; Ch. 28.

138.  Keith, J. M.; Jacobsen, E. N. “Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide – PYBOX Complexes Organic Lett. 2004, 6, 153–155.

139.  Raheem, I. T.; Goodman, S. N.; Jacobsen, E. N. “Catalytic Asymmetric Total Syntheses of Quinine and Quinidine,” J. Am. Chem. Soc. 2004, 126, 706–707.

140.  Nielsen, L. C. P.; Stevenson, C. P.; Blackmond, D.G.; Jacobsen, E. N. “Mechanistic Investigation Leads to a Synthetic Improvement in the Hydrolytic Kinetic Resolution of Terminal Epoxides,” J. Am. Chem. Soc. 2004, 126, 1360–1362.

141.  Liu, Y.; DiMare, M.; Marchese, S. A.; Jacobsen, E. N.; Jasmin, S. “Hydrolytic Kinetic Resolution of Epoxides,” U.S. Patent #6,693,206 issued 2/17/04.

142.  Joly, G. D.; Jacobsen, E. N. “Thiourea-Catalyzed Enantioselective Hydrophosphonylation of Imines: Practical Access to Enantiomerically Enriched a-Amino Phosphonic Acids,” J. Am. Chem. Soc. 2004, 126, 4102–4103.

143.  Taylor, M. S.; Jacobsen, E. N. “Asymmetric Catalysis in Complex Target Synthesis,” Proc. Nat. Acad. Sci. 2004, 101, 5368–5373.

144.  Jacobsen, E. N., Sigman, M. S. "Parallel Combinatorial Approach to the Discovery and Optimization of Catalysts and Uses Thereof," U.S. Patent #6,709,824 B2 issued 3/23/04.

145.  Larrow, J. F.; Jacobsen, E. N. “Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes,” Topics Organomet. Chem. 2004, 6, 123–152.

146.  Kim, S.; Jacobsen, E. N. “General Catalytic Synthesis of Highly Enantiomerically Enriched Terminal Aziridines from Racemic Epoxides,” Angew. Chem. Int. Ed. 2004, 43, 3952–3954.

147.  Sammis, G. M.; Danjo, H.; Jacobsen, E. N. “Cooperative Dual Catalysis: Application to the Highly Enantioselective Conjugate Cyanation of Unsaturated Imides,” J. Am. Chem. Soc. 2004, 126, 9928–9929.

148.  Taylor, M. S.; Jacobsen, E. N. “Highly Enantioselective Catalytic Acyl-Pictet–Spengler Reactions,” J. Am. Chem. Soc. 2004, 126, 10558–10559.

149.  Vanderwal, C. D.; Jacobsen, E. N. “Highly Enantioselective Hydration of a,b-Unsaturated Imides by Al-Catalyzed Conjugate Addition of Oxime Nucleophiles,” J. Am. Chem. Soc. 2004, 126, 14724–14725.

150.  Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F. “Hydrolytic Kinetic Resolution of Cyclic Substrates,” U.S. Patent #6,800,766 issued 10/5/04.

151.  Doyle, A. G.; Jacobsen, E. N. “Enantioselective Alkylations of Tributyltin Enolates Catalyzed by Cr(salen)Cl: Access to Enantiomerically Enriched All Carbon Quaternary Centers,” J. Am. Chem. Soc. 2005, 127, 62–63.

152.  Yoon, T. P.; Jacobsen, E. N. “Highly Enantioselective Thiourea-catalyzed Nitro-Mannich Reaction,” Angew. Chem. Int. Ed. 2005, 44, 466–468.

153.  Jacobsen, E. N., Sigman, M. S. "Main Group Metal-Based Asymmetric Catalysts and Applications Thereof," U.S. Patent #6,844,448 issued 1/18/05.

154.  Taylor, M. S.; Zalatan, D. N.; Lerchner, A. M.; Jacobsen, E. N. “Highly Enantioselective Conjugate Additions to a,b-Unsaturated Ketones Catalyzed by a (salen)Al Complex,” J. Am. Chem. Soc. 2005, 127, 1313–1317.

155.  Gandelman, M.; Jacobsen, E. N. “Highly Enantioselective Catalytic Conjugate Addition of N-Heterocycles to a,b-Unsaturated Ketones and Imides,” Angew. Chem. Int. Ed. 2005, 44, 2393–2397.

156.  Wenzel, A. G.; Jacobsen, E. N. “Asymmetric Catalysis in the Enantioselective Synthesis of b-Amino Acids,” in Enantioselective Synthesis of beta-Amino Acids, Juaristi, E.; Soloshonok, V., Eds.; Wiley-VCH: New York, 2005; Chapter 4.

157.  Fuerst, D. E.; Jacobsen, E. N. “Thiourea-Catalyzed Enantioselective Cyanosilylation of Ketones,” J. Am. Chem. Soc. 2005, 127, 8964–8965.

158.  Jarvo, E. R.; Lawrence, B. M.; Jacobsen, E. N. “Highly Enantio- and Regioselective Quinone Diels–Alder Reactions Catalyzed by a Tridentate (Schiff Base)Cr(III) Complex,” Angew. Chem. Int. Ed. 2005, 44, 6043–6046.

159.  Boezio, A. A.; Jarvo, E. R.; Lawrence, B. M.; Jacobsen, E. N. “Efficient Total Syntheses of (–)-Colombiasin A and (–)-Elisapterosin B: Application of the Cr-Catalyzed Asymmetric Quinone Diels–Alder Reaction,” Angew. Chem. Int. Ed. 2005, 44, 6046–6050.

160.  Taylor, M. S.; Jacobsen, E. N. “Enantioselective Thiourea-Catalyzed Acyl-Mannich Reactions of Isoquinolines,” Angew. Chem. Int. Ed. 2005, 44, 6700–6704.

161.  Raheem, I. T.; Jacobsen, E. N. “Highly Enantioselective Aza-Baylis–Hillman Reactions Catalyzed by Chiral Thiourea Derivatives,” Adv. Synth. Catal. 2005, 347, 1701–1708.

162.  Chavez, D. E.; Jacobsen, E. N. “An Efficient, Highly Diastereo- and Enantioselective Hetero-Diels–Alder Catalyst.  Preparation of (2S,6R)-6-(tert-Butyldimethylsilyloxymethyl)-2-Methoxy-2,5-Dihydropyran,” Organic Synth. 2005, 82, 34–42.

163.  Nielsen, L. P. C. Jacobsen, E. N.“Catalytic, Asymmetric Epoxide Ring-Opening Chemistry,” in Aziridines and Epoxides in Organic Synthesis, Yudin, A., Ed.; Wiley, New York; 2006, Ch. 10.

164.    Taylor, M. S.; Jacobsen, E. N. “Asymmetric Catalysis by Chiral Hydrogen Bond Donors,” Angew. Chem. Int. Ed. 2006, 45, 1520–1543.

165.    Balskus, E. P.; Jacobsen, E. N. “a,b-Unsaturated b-Silyl Imide Substrates for Catalytic, Enantioselective Conjugate Additions: A Total Synthesis of (+)-Lactacystin and the Discovery of a New Proteasome Inhibitor,” J. Am. Chem. Soc. 2006, 128, 6810–6812.

166.    Huang, H.; Jacobsen, E. N. “Highly Enantioselective Direct Conjugate Addition of Ketones to Nitroalkenes Promoted by A Chiral Primary Amine-Thiourea Catalyst,” J. Am. Chem. Soc. 2006, 128, 7170–7171.

167.    Lalonde, M. P.; Chen, Y.; Jacobsen, E. N. “A Chiral Primary Amine-Thiourea Catalyst for the Highly Enantioselective Direct Conjugate Addition of a,a-Disubstituted Aldehydes to Nitroalkenes,” Angew. Chem. Int. Ed. 2006, 45, 6366–6370.

168.  Stevenson, C. P.; Nielsen, L. P. C. Jacobsen, E. N. “Preparation of (S)-Methyl Glycidate via Hydrolytic Kinetic Resolution,” Org. Synth. 2006, 83, 55, 162–166.

169.  Yoon, T. P.; Jacobsen, E. N. “Arenecarboxylic Acids,” Science of Synthesis 2006, 20a, 533–549.

170.  Vanderwal, C. D.; Jacobsen, E. N. “Alk-2-enoic Acids,” Science of Synthesis 2006, 20a, 551–568.

171.  Yoon, T. P.; Jacobsen, E. N. “Arenecarboxylic Acid Esters,” Science of Synthesis 2006, 20b, 1285–1304.

172.  Vanderwal, C. D.; Jacobsen, E. N. “Alk-2-enoic Acid Esters,” Science of Synthesis 2006, 20b, 1305–568.

173.  Tan, K. L.; Jacobsen, E. N. “Indium-Mediated Asymmetric Allylation of Acylhydrazones Using a Chiral Urea Catalyst,” Angew. Chem. Int. Ed. 2007, 46, 1315–1317.

174.  Doyle, A. G.; Jacobsen, E. N. “Enantioselective Alkylation of Acyclic a,a-Disubstituted Tributyltin Enolates Catalyzed by a {Cr(salen)} Complex,” Angew. Chem. Int. Ed. 2007, 46, 3701–3705.

175.  Balskus, E. P.; Jacobsen, E. N. “Asymmetric Catalysis of the Transannular Diels–Alder Reaction,” Science 2007, 317, 1736–1740.

176.    Raheem, I. T.; Thiara, P. V.; Peterson, E. A.; Jacobsen, E. N. “Enantioselective Pictet–Spengler-Type Cyclizations of Hydroxylactams: H-Bond Donor Catalysis by Anion Binding,” J. Am. Chem. Soc. 2007, 129, 13404–13405.

177.    Zuend, S. J.; Jacobsen, E. N. "Cooperative Catalysis by Tertiary Amino-Thioureas: Mechanism and Basis for Enantioselectivity of Ketone Cyanosilylation," J. Am. Chem. Soc. 2007, 129, 15872–15883.

178.    Doyle, A. G.; Jacobsen, E. N. “Small-Molecule H-Bond Donors in Asymmetric Catalysis," Chem. Rev. 2007, 107, 5713–5743.

179.      Grachan, M. L.; Tudge, M. T.; Jacobsen, E. N. “Enantioselective Catalytic Carbonyl-ene Cyclization Reactions,” Angew. Chem., Int. Ed. 2008, 47, 1469–1472.

180.      Mazet, C.; Jacobsen, E. N. “Dimeric (salen)Al Complexes Display Expanded Scope in the Conjugate Cyanation of a b-Unsaturated Imides,” Angew. Chem., Int. Ed. 2008, 47, 1762–1765.

181.      Mergott, D. J.; Zuend, S. J.; Jacobsen, E. N. “Catalytic Asymmetric Total Synthesis of (+)-Yohimbine,” Org. Lett. 2008, 10, 745–748.

182.      Belser, T.; Jacobsen, E. N. “Cooperative Catalysis in the Hydrolytic Kinetic Resolution of Epoxides by chiral [(salen)Co^III] Complexes Immobilized on Gold Colloids,” Adv. Synth. Catal. 2008, 350, 967–971.

183.      Raheem, I. T.; Thiara, P. V.; Jacobsen, E. N. “Regio- and Enantioselective Cyclization of Pyrroles onto N-Acyliminium Ions,” Org. Lett. 2008, 10, 1577–1580.

184.      Fang, Y.-Q.; Jacobsen, E. N. “Cooperative, Highly Enantioselective Phosphinothiourea Catalysis of Imine-Allene [3+2] Cycloadditions,” J. Am. Chem. Soc. 2008, 130, 5660–5661.

185.      Reisman, S. E.; Doyle, A. G.; Jacobsen, E. N. “Enantioselective Thiourea-Catalyzed Additions to Oxocarbenium Ions,” J. Am. Chem. Soc. 2008, 130, 7198–7199.

186.      Uyeda, C.; Jacobsen, E. N. “Enantioselective Claisen Rearrangements with a Hydrogen-Bond Donor Catalyst,” J. Am. Chem. Soc. 2008, 130, 9228–9229.

187.      Watson, M. P.; Jacobsen, E. N. “Asymmetric Intramolecular Arylcyanation of Unactivated Olefins via C–CN Bond Activation,” J. Am. Chem. Soc. 2008, 130, 12594–12595.

188.      Groll, M.; Balskus, E. P.; Jacobsen, E. N., “Structural Analysis of Spiro β-Lactone Proteasome Inhibitors,” J. Am. Chem. Soc. 2008, 130, 14981–14983.

189.      Klausen, R. S.; Jacobsen, E. N. “Weak Brønsted Acid−Thiourea Co-catalysis: Enantioselective, Catalytic Protio-Pictet−Spengler Reactions,” Org. Lett. 2009, 11, 887–890.

190.      Loy, Rebecca N.; Jacobsen, E. N. “Enantioselective Intramolecular Openings of Oxetanes Catalyzed by (salen)Co(III) Complexes: Access to Enantioenriched Tetrahydrofurans,” J. Am. Chem. Soc. 2009 131, 2786–2787.