| RESEARCH PUBLICATIONS
Eric N. Jacobsen
- Wenke, G.; Jacobsen, E. N.; Totten, G. E.;
Karydas, A. C.; Rhodes, Y. E. “Silyl Ketene Acetal Chemistry:
Steric Limitations in Lewis Acid-Promoted Addition of Ketones,”
Synth. Commun. 1983, 13, 449.
- Jacobsen, E. N.; Bergman, R. G. “Synthesis,
Crystal and Molecular Structure, and Reactions of the Bridging
Vinylidenedicobalt Complex (µ-CCH2)(CpCoCO)2.
Reaction with Molybdenum Hydrides to Give a Heteronuclear Cluster
Complex,” Organometallics 1984, 3, 329.
- Jacobsen, E. N.; Totten, G. E.; Wenke, G.;
Karydas, A. C.; Rhodes, Y. E. “Steric Effects on the Titanium
Tetrachloride-Promoted Dimerization of Silyl Ketene Acetals,”
Synth. Commun. 1985, 15, 301.
- Jacobsen, E. N.; Bergman, R. G. “Synthesis
and Chemistry of a Bridging Vinylidenedicobalt Complex. Evidence
for a Non-Chain Radical Mechanism in its Reaction with Metal Hydrides
to Give Heteronuclear Clusters,” J. Am. Chem. Soc. 1985,
107, 2023.
- Jacobsen, E. N.; Trost, M. K.; Bergman,
R. G. “Synthesis of Organometallic Heterodinuclear µ-Oxo
Complexes by Extrusion of Alkenes from Zirconium/Tungsten Oxaalkyl
Complexes,” J. Am. Chem. Soc. 1986, 108,
8092.
- Jacobsen, E. N.; Markó, I. E.; Mungall,
W. S.; Schröder, G. W.; Sharpless, K. B. “Asymmetric Dihydroxylation
via Ligand-Accelerated Catalysis,” J. Am. Chem. Soc. 1988,
110, 1968.
- Jacobsen, E. N.; Goldberg, K. I.; Bergman,
R. G. “Rapid, Reversible Intramolecular C-H Oxidative Addition
and H-Exchange in a Heterodinuclear 'Early-Late' Transition Metal
Complex,” J. Am. Chem. Soc. 1988, 110, 3706.
- Jacobsen, E. N.; Markó, I. E.; France, M.
B.; Svendsen, J. S.; Sharpless, K. B. “Kinetic Role of Alkaloid
Ligands in Asymmetric Catalytic Dihydroxylation,” J. Am. Chem.
Soc. 1989, 111, 737.
- Wai, J. S. M.; Markó, I. E.; Svendsen, J.
S.; Finn, M. G.; Jacobsen, E. N.; Sharpless, K. B. “A Mechanistic
Insight Leads to a Greatly Improved Osmium-Catalyzed Asymmetric
Dihydroxylation Process,” J. Am. Chem. Soc. 1989,
111, 1123.
- Svendsen, J. S.; Markó, I. E.; Jacobsen,
E. N.; Pulla Rao, Ch.; Bott, S.; Sharpless, K. B. “On the Structure
of Osmium Tetroxide-Cinchona Alkaloid Complexes,” J. Org. Chem.
1989, 54, 2263.
- Zhang, W.; Loebach, J. L.; Wilson, S. R.;
Jacobsen, E. N. “Enantioselective Epoxidation of Unfunctionalized
Olefins Catalyzed by (salen)Manganese Complexes,” J. Am. Chem.
Soc. 1990, 112, 2801-2803.
- Zhang, W.; Jacobsen, E. N. “Preparation
of trans-1,2-Diamino-1,2-Dimethylcyclohexane via Highly
Stereoselective Olefin Oxidation by Dinitrogen Tetroxide,” Tetrahedron
Lett. 1991, 32, 1711-1714.
- Zhang, W.; Jacobsen, E. N. “Asymmetric Epoxidation
with Sodium Hypochlorite Catalyzed by Readily Available Chiral
Mn(III) Salen Complexes,” J. Org. Chem. 1991, 56,
2296-2298.
- Jacobsen, E. N.; Zhang, W.; Muci, A. R.;
Ecker, J. R.; Deng, L. “Highly Enantioselective Epoxidation Catalysts
Derived from 1,2-Diaminocyclohexane,” J. Am. Chem. Soc.
1991, 113, 7063-7064.
- Fu, H.; Look, G. C.; Zhang, W.; Jacobsen,
E. N.; Wong, C.-H. “Mechanistic Study of a Synthetically Useful
Mono-oxygenase Model Using Hypersensitive Probes cis and
trans-2-phenyl-1-Vinylcyclopropane,” J. Org. Chem.
1991, 56, 6497-6500.
- Jacobsen, E. N.; Güler, M. L.; Zhang, W.
“Electronic Tuning of Asymmetric Catalysts,” J. Am. Chem. Soc.
1991, 113, 6703-6704.
- Jacobsen, E. N. “Asymmetric Synthesis,”
in 1992 Yearbook of Science & Technology, McGraw-Hill,
Inc., New York; 1991, p. 34.
- Lee, N. H.; Muci, A. R.; Jacobsen, E. N.
“Enantiomerically Pure Epoxychromans via Asymmetric Catalysis,”
Tetrahedron Lett. 1991, 32, 5055-5058.
- Lee, N. H.; Jacobsen, E. N. “Enantioselective
Epoxidation of Conjugated Dienes and Enynes. Trans-Epoxides from
Cis-Olefins,” Tetrahedron Lett. 1991, 32,
6533-6536.
- Deng, L.; Jacobsen, E. N. “A Practical,
Highly Enantioselective Synthesis of the Taxol Side Chain via
Asymmetric Catalysis,” J. Org. Chem. 1992, 57,
4320-4323.
- Pospisil, P. J.; Jacobsen, E. N. “A Substoichiometric
Pyridine•Lithium Enolate Complex: Solution and X-Ray Data, and
Implications to Catalysis in the Aldol Reaction,” J. Am. Chem.
Soc. 1992, 114, 7585-7587.
- Palucki, M.; Hanson, P.; Jacobsen, E. N.
“Asymmetric Oxidation of Sulfides with H2O2
Catalyzed by (salen)Mn(III) Complexes,” Tetrahedron Lett.
1992, 33, 7111-7114.
- Baudry, M.; Etienne, S.; Bruce, A.; Palucki,
M.; Jacobsen, E.; Malfroy, B. “Salen-Manganese Complexes are Superoxide
Dismutate Mimics,” Biochem. Biophys. Res. Commun. 1993,
192, 964-968.
- Li, Z.; Conser, K. R.; Jacobsen, E. N.
“Asymmetric Alkene Aziridination with Readily Available Chiral
Diimine-Based Catalysts,” J. Am. Chem. Soc. 1993,
115, 5326-5327.
- Allain, E. A.; Hager, L. P.; Deng, L.; Jacobsen,
E. N. “Highly Enantioselective Epoxidation of Disubstituted Alkenes
with Hydrogen Peroxide Catalyzed by Chloroperoxidase,” J. Am.
Chem. Soc. 1993, 115, 4415-4416.
- Heinze, K. F.; Allen, J. L.; Jacobsen, E.
N. “Encouraging Tomorrow's Chemists: University Outreach Program
Bringing Hands-On Experiments to Local Students,” J. Chem.
Educ. 1995, 72, 167-169.
- Jacobsen, E. N. “Asymmetric Catalytic Epoxidation
of Unfunctionalized Olefins,” in Catalytic Asymmetric Synthesis,
Ojima, I., Ed.; VCH: New York, 1993; Chapter 4.2.
- Fields, L. B.; Jacobsen, E. N. “Synthesis
and Characterization of Chiral Bimetallic Complexes Bearing Hard
and Soft Lewis Acidic Sites,” Tetrahedron: Asymmetry 1993,
4, 2229-2240.
- Chang, S.; Lee, N. H.; Jacobsen, E. N. “Regio-
and Enantioselective Epoxidation of Conjugated Polyenes. Formal
Synthesis of LTA4 Methyl Ester,” J. Org. Chem.
1993, 58, 6939-6941.
- Zhang, W.; Lee, N. H.; Jacobsen, E. N. “Non-Stereospecific
Mechanisms in Asymmetric Addition to Alkenes Result in Enantiodifferentiation
after the First Irreversible Step,” J. Am. Chem. Soc. 1994,
116, 425-426.
- Jacobsen, E. N.; Deng, L.; Furukawa, Y.;
Martínez, L. E. “Enantioselective Catalytic Epoxidation of Cinnamate
Esters,” Tetrahedron 1994, 50, 4323-4334.
- Chang, S.; Heid, R. M.; Jacobsen, E. N.
“Enantioselective Epoxidation of Cyclic 1,3-Dienes Catalyzed by
a Sterically and Electronically Optimized (Salen)Mn Complex,”
Tetrahedron Lett. 1994, 35, 669-672.
- Larrow, J. F.; Jacobsen, E. N.; Gao, Y.;
Hong, Y.; Nie, X.; Zepp, C. M. “A Practical Process for the Large-Scale
Preparation of (R,R)-N,N’-Bis(3,5-Di-tert-butylsalicylidene)-1,2-Cyclohexanediaminomanganese
(III) Chloride, a Highly Enantioselective Epoxidation Catalyst,”
J. Org. Chem. 1994, 59, 1939-1940.
- Chang, S.; Galvin, J. M.; Jacobsen, E. N.
“Effect of Chiral Quaternary Ammonium Salts on (salen)Mn-Catalyzed
Epoxidation of cis-Olefins. A Highly Enantioselective, Catalytic
Route to Trans Epoxides,” J. Am. Chem. Soc. 1994,
116, 6937-6938.
- Brandes, B. D.; Jacobsen, E. N. “Highly
Enantioselective, Catalytic Epoxidation of Trisubstituted Olefins,”
J. Org. Chem. 1994, 59, 4378-4380.
- Palucki, M.; Pospisil, P. J.; Zhang, W.;
Jacobsen, E. N. “Highly Enantioselective, Low Temperature Epoxidation
of Terminal Olefins,” J. Am. Chem. Soc. 1994, 116,
9333-9334.
- Larrow, J. F.; Jacobsen, E. N. “Kinetic
Resolution of 1,2-Dihydronaphthalene Oxide and Related Epoxides
via Asymmetric C–H Hydroxylation,” J. Am. Chem. Soc. 1994,
116, 12129-12130.
- Jacobsen, E. N.; Finney, N. S. “Synthetic
and Biological Catalysts for Chemical Synthesis: How to Assess
Practical Utility,” Chem. Biol. 1994, 1,
85-90.
- Hansen, K. H.; Finney, N. S.; Jacobsen,
E. N. “Carbenoid Transfer to Imines: A New Asymmetric Catalytic
Synthesis of Aziridines,” Angew. Chem. Int. Ed. Engl. 1995,
34, 676-678.
- Jacobsen, E. N.; Galvin, J. M. “Sodium Hypochlorite,”
in Encyclopedia of Reagents for Organic Synthesis, Volume
7, Paquette, L.A., Ed.; Wiley: New York, 1995, pp. 4580-4585.
- Jacobsen, E. N. “Sodium Hypochlorite-Chiral
Manganese (III) Salen Complexes,” in Encyclopedia of Reagents
for Organic Synthesis, Volume 7, Paquette, L.A., Ed.; Wiley:
New York, 1995, pp. 4585-4586.
- Martínez, L. E.; Leighton, J. L.; Carsten,
D. H.; Jacobsen, E. N. “Highly Enantioselective Ring Opening of
Epoxides Catalyzed by Chiral (salen)Cr(III) Complexes,” J.
Am. Chem. Soc. 1995, 117, 5897-5898.
- Li, Z.; Quan, R. W.; Jacobsen, E. N. “Mechanistic
Study of the (diimine)Cu-Catalyzed Asymmetric Azridination of
Alkenes. Nitrene Transfer via Ligand-Accelerated Catalysis,”
J. Am. Chem. Soc. 1995, 117, 5889-5890.
- Jacobsen, E. N. “Transition Metal Catalyzed
Oxidations: Asymmetric Epoxidation ,” in Comprehensive Organometallic
Chemistry II, Vol. 12, Wilkinson, G.; Stone, F. G. A.; Abel,
E. W.; Hegedus, L. S., Eds.; Pergamon: New York; 1995, pp. 1097-1135.
- Jacobsen, E. N. “Fundamental and Applied
Studies in Asymmetric Oxidation Catalysis,” in Stereoselective
Reactions of Metal-Activated Molecules, Werner, H. and Sundmeyer,
J., Eds.; Vieweg: New York; 1995, pp. 17-26.
- Brandes, B. D.; Jacobsen, E. N. “Enantioselective
Catalytic Epoxidation of Tetrasubstituted Olefins,” Tetrahedron
Lett. 1995, 36, 5123-5126.
- Palucki, M.; McCormick, G. J.; Jacobsen,
E. N. “Low Temperature Asymmetric Epoxidation of Unfunctionalized
Olefins Catalyzed by (salen)Mn(III) Complexes,” Tetrahedron
Lett. 1995, 36, 5457-5460.
- Vander Velde, S. L.; Jacobsen, E. N. “Kinetic
Resolution of Racemic Chromenes via Asymmetric Epoxidation; Synthesis
of (+)-Teretifolione B,” J. Org. Chem. 1995, 60,
5380-5381.
- Leighton, J.L.; Jacobsen, E.N. “Efficient
Synthesis of (R)-4-Trimethylsilyloxy-2- cyclopenenone by Enantioselective
Catalytic Epoxide Ring Opening,” J. Org.Chem. 1996,
61, 389-390.
- Larrow, J.F.; Schaus, S.E.; Jacobsen, E.N.
“Kinetic Resolution of Terminal Epoxides via Highly Regioselective
and Enantioselective Ring Opening with TMSN3. An Efficient,
Catalytic Route to 1,2-Aminoalcohols,” J. Am. Chem. Soc.
1996, 118, 7420-7421.
- Pospisil, P.J.; Carsten, D.H.; Jacobsen,
E.N. “X-Ray Structural Studies of Highly Enantioselective Mn(salen)
Epoxidation Catalysts,” Chem. Eur. J. 1996, 2,
974-980.
- Quan, R.W.; Li, Z.; Jacobsen, E.N. “Enantioselective
Binding of Prochiral Olefins to a Chiral Catalyst via Simultaneous
Face-Face and Edge-Face Aromatic Interactions,” J. Am. Chem.
Soc. 1996, 118, 8156-8157.
- Francis, M.B.; Finney, N.S.; Jacobsen, E.N.
“Combinatorial Approach to the Discovery of Novel Coordination
Compounds," J. Am. Chem. Soc. 1996, 118,
8983-8984.
- Martinez, L.E.; Nugent, W.A.; Jacobsen,
E.N. “Highly Efficient and Enantioselective Synthesis of Carbocyclic
Nucleoside Analogs Using Selective Early Transition Metal Catalysis,”
J. Org. Chem. 1996, 61, 7963-7966.
- Schaus, S.E.; Jacobsen, E.N. “Dynamic Kinetic
Resolution of Epichlorohydrin via Enantioselective Catalytic Ring
Opening with TMSN3. Practical Synthesis of Aryl Oxazolidinone
Antibacterial Agents,” Tetrahedron Lett. 1996, 37,
7939-7942.
- Hansen, K.B.; Leighton, J.L.; Jacobsen,
E.N. “On the Mechanism of Asymmetric Nucleophilic Ring-Opening
of Epoxides Catalyzed by (Salen)Cr(III) Complexes,” J. Am.
Chem. Soc. 1996, 118, 10924-10925.
- Jacobsen, E.N.; Kakiuchi, F.; Konsler, R.G.;
Larrow, J.F.; Tokunaga, M. “Enantioselective Catalytic Ring Opening
of Epoxides with Carboxylic Acids,” Tetrahedron Lett. 1997,
38, 773-776.
- Wu, M.H.; Jacobsen, E.N. “An Efficient Formal
Synthesis of Balanol via the Asymmetric Epoxide Ring Opening Reaction,”
Tetrahedron Lett. 1997, 38, 1693-1696.
- Schaus, S.E.; Larrow, J.F.; Jacobsen, E.N.
“Practical Synthesis of Enantiopure Cyclic 1,2-Aminoalcohols via
Catalytic Asymmetric Ring Opening of Meso Epoxides,” J. Org.
Chem. 1997, 62, 4197-4199.
- Jacobsen, E.N.; Zhang, W.; Deng, L. “Chiral
Catalysts and Epoxidation Reactions Catalyzed Thereby,” U.S. Patent
No. 5, 637, 739 issued 6/10/97.
- Jacobsen, E.N.; Zhang, W.; Deng, L. “Chiral
Catalysts and Epoxidation Reactions,” U.S. Patent No. 5, 663,
393 issued 9/2/97.
- Tokunaga, M.; Larrow, J.F.; Kakiuchi, F.;
Jacobsen, E.N. “Asymmetric Catalysis with Water: Efficient Kinetic
Resolution of Terminal Epoxides by Means of Catalytic Hydrolysis,”
Science 1997, 277, 936-938.
- Finney, N.S.; Pospisil, P.J.; Chang, S.;
Palucki, M.; Hansen, K.B.; Jacobsen, E.N. “On the Viability of
Metallaoxetane Intermediates in the (salen)Mn-Catalyzed Asymmetric
Epoxidation Reaction,” Angew. Chem. Int. Ed. Engl. 1997,
36, 1720-1723.
- Jacobsen, E.N.; Martinez, L.E.; Leighton,
J.L. “Stereoselective Ring Opening Reactions,” U.S. Patent No.
5, 665, 890 issued 9/9/97.
- Brandes, B.D.; Jacobsen, E.N. “Synthesis
of Enantiopure 3-Chlorostyrene Oxide via an Asymmetric Epoxidation/Hydrolytic
Kinetic Resolution Sequence,” Tetrahedron: Asymmetry 1997,
8, 3927-3933.
- Larrow, J.F.; Jacobsen, E.N. “(R,R)-N,N'-Bis(3,5-Di-tert-butylsalicylidene)-1,2-
Cyclohexanediaminomanganese (III) Chloride, a Highly Enantioselective
Epoxidation Catalyst,” Organic Synth. 1997, 75,
1-10.
- Schaus, S.E.; Brånalt, J.E.; Jacobsen, E.N.
“Asymmetric Hetero-Diels-Alder Reactions Catalyzed by Chiral (salen)Chromium(III)
Complexes,” J. Org. Chem. 1998, 63, 403-405.
- Palucki, M.; Finney, N.S.; Pospisil, P.J.;
Güler, M.L.; Ishida, T.; Jacobsen, E.N. “The Mechanistic Basis
for Electronic Effects on Enantioselectivity in the (salen)Mn-Catalyzed
Epoxidation Reaction,” J. Am. Chem. Soc. 1998, 120,
948-954.
- Sigman, M.S.; Jacobsen, E.N. “Schiff Base
Catalysts for the Asymmetric Strecker Reaction Identified and
Optimized from Parallel Synthetic Libraries,” J. Am. Chem.
Soc. 1998, 120, 4901-4902.
- Sigman, M.S.; Jacobsen, E.N. “Enantioselective
Addition of Hydrogen Cyanide to Imines Catalyzed by a Chiral (salen)Al(III)
Complex,” J. Am. Chem. Soc. 1998, 120, 5315-5316.
- Francis, M.B.; Jamison, T.F.; Jacobsen,
E.N. “Combinatorial Libraries of Transition Metal Complexes, Catalysts,
and Materials,” Curr. Opinion Chem. Biol. 1998,
2, 422-428.
- Schaus, S.E.; Brånalt, J.E.; Jacobsen, E.N.
“Total Synthesis of Muconin by Efficient Assembly of Chiral Building
Blocks,” J. Org. Chem. 1998, 63, 4876-4877.
- Wu, M.H.; Jacobsen, E.N. “Asymmetric Ring
Opening of Meso Epoxides with Thiols: Enantiomeric Enrichment
Using a Bifunctional Nucleophile,” J. Org. Chem. 1998,
63, 5252-5254.
- Annis, D.A.; Jacobsen, E.N. “Solid Phase
Synthesis of Cyclic RGD Peptide Derivatives via Asymmetric Catalysis:
Stereochemistry as a Diversity Element,” Angew. Chem. Int.
Ed. 1998, 37, 1907-1909.
- Furrow, M.E.; Schaus, S.E.; Jacobsen, E.N.
“Practical Access to Highly Enantioenriched C-3 Building Blocks
via Hydrolytic Kinetic Resolution,” J. Org. Chem. 1998,
63, 6776-6777.
- Konsler, R.G.; Karl, J.; Jacobsen, E.N.
“Cooperative Asymmetric Catalysis Using Dimeric Salen Complexes,”
J. Am. Chem. Soc. 1998, 120, 10780-10781.
- Dakin, L. A.; Schaus, S.E.; Jacobsen, E.N.;
Panek, J.S., “Carbenoid Insertions into the Silicon-Hydrogen Bond
Catalyzed by Chiral Copper (I) Schiff Base Complexes,” Tetrahedron
Lett. 1998, 39, 8947-8950.
- Lebel, H.; Jacobsen, E.N. “Enantioselective
Total Synthesis of Taurospongin A,” J. Org. Chem. 1998,
63, 9624-9625. [pdf]
- Larrow, J.F.; Roberts, E.; Verhoeven, T.R.;
Ryan, K.M.; Senanayake, C.H.; Reider, P.J.; Jacobsen, E.N. “(1S,2R)-1-Aminoindan-2-ol,”
Organic Synth. 1998, 76, 46-56.
- Hinterding, K.; Jacobsen, E.N. “Regioselective
Carbomethoxylation of Chiral Epoxides: a New Route to Enantiomerically
Pure β-Hydroxyesters,” J. Org. Chem. 1999,
64, 2164-2165. [pdf]
- Francis, M. B.; Jacobsen, E. N. “Discovery
of Novel Catalysts for Alkene Epoxidation Using Metal-Binding
Combinatorial Libraries,” Angew. Chem. Int. Ed. 1999,
38, 937-941. [pdf]
- Annis, D. A.; Jacobsen, E. N. “Polymer-Supported
Chiral Co(Salen) Complexes: Synthetic Applications and Mechanistic
Investigations in the Hydrolytic Kinetic Resolution of Terminal
Epoxides,” J. Am. Chem. Soc. 1999, 121, 4147-4154.
[pdf]
- Senanayake, C. H.; Jacobsen, E. N. “Chiral
(Salen)Mn(III) Complexes in Asymmetric Epoxidations: Practical
Synthesis of cis-Aminoindanol and Its Application to Enantiopure
Drug Synthesis,” in Process Chemistry in the Pharmaceutical
Industry, Gadamasetti, K. G., Ed.; Dekker: New York, 1999,
pp. 347-368.
- Ready, J. M.; Jacobsen, E. N. “Asymmetric
Catalytic Synthesis of α-Aryloxy Alcohols: Kinetic
Resolution of Terminal Epoxides via Highly Enantioselective Ring
Opening with Phenols,” J. Am. Chem. Soc. 1999, 121,
6086-6087. [pdf]
- Wu, M. H.; Hansen, K. B.; Jacobsen, E. N.
“Regio- and Enantioselective Cyclization of Epoxy Alcohols Catalyzed
by a [CoIII(salen)] Complex,” Angew. Chem. Int.
Ed. 1999, 38, 2012-2014. [pdf]
- Jacobsen, E. N.; Martinez, L. E.; Leighton,
J. L. “Stereoselective Ring Opening Reactions,” U.S. Patent No.
5, 929, 232 issued 7/27/99.
- Dossetter, A. G.; Jamison, T. F.; Jacobsen,
E. N. “Highly Enantio- and Diastereoselective Hetero-Diels-Alder
Reactions Catalyzed by New Chiral Tridentate Chromium Catalysts,”
Angew. Chem. Int. Ed. 1999, 38,
2398-2400. [pdf]
- Lebel, H.; Jacobsen, E. N. “Chromium Catalyzed
Kinetic Resolution of 2,2-Disubstituted Epoxides,” Tetrahedron
Lett. 1999, 40, 7303-7306. [pdf]
- Myers, J. K.; Jacobsen, E. N. “Asymmetric
Synthesis of β-Amino Acid Derivatives via Catalytic
Conjugate Addition of Hydrazoic Acid to Unsaturated Imides,” J.
Am. Chem. Soc. 1999, 121, 8959-8960.
[pdf]
- Jacobsen, E. N.; Wu, M. H. “Epoxidation
of Alkenes Other than Allylic Alcohols,” in Comprehensive Asymmetric
Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.;
Springer: New York; 1999, Chapter 18.2.
- Jacobsen, E. N.; Wu, M. H. “Ring Opening
of Epoxides and Related Reactions,” in Comprehensive Asymmetric
Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.;
Springer: New York; 1999, Chapter 35.
- Jacobsen, E. N. “Aziridination,” in Comprehensive
Asymmetric Catalysis, Jacobsen, E. N.; Pfaltz, A.; Yamamoto,
H., Eds.; Springer: New York; 1999, Chapter 17.
- Jacobsen, E. N. “Future Perspectives in
Asymmetric Catalysis,” in Comprehensive Asymmetric Catalysis,
Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New
York; 1999, Chapter 42.
- Peukert, S.; Jacobsen, E. N. “Enantioselective
Parallel Synthesis Using Polymer-Supported Chiral Co(Salen) Complexes,”
Org. Lett. 1999, 1, 1245-1248. [pdf]
- Li, Z.; Fernandez, M.; Jacobsen, E. N. “Enantioselective
Ring-opening of meso Aziridines Catalyzed by Tridentate Schiff-base
Chromium(III) Complexes,” Org. Lett. 1999, 1,
1611-1613. [pdf]
- Jacobsen, E. N.; Breinbauer, R. “Nickel
Comes Full Cycle,” (Perspective) Science 2000, 287,
437.
- Sigman, M. S.; Vachal, P.; Jacobsen, E.
N. “A General Catalyst for the Asymmetric Strecker Reaction,”
Angew. Chem. Int. Ed. Engl. 2000, 39, 1279-1281.
[pdf]
- Vachal, P.; Jacobsen, E. N. “Enantioselective
Catalytic Addition of HCN to Ketoimines. Catalytic Synthesis
of Quaternary Amino Acids” Org. Lett. 2000, 2,
867-870. [pdf]
- Schaus, S. E.; Jacobsen, E. N. “Asymmetric
Ring-Opening of Meso-Epoxides with TMSCN Catalyzed by (pybox)Lanthanide
Complexes,” Org. Lett. 2000, 2, 1001-1004.
[pdf]
- Jacobsen, E. N. “Asymmetric Catalysis of Epoxide Ring-Opening Reactions,”
Acc. Chem. Res. 2000, 33, 421-431. [pdf]
- Breinbauer, R.; Jacobsen, E. N. “Cooperative Asymmetric Catalysis with
Dendrimeric Co(salen) Complexes,” Angew. Chem. Int. Ed.
2000, 39, 3604-3607. [pdf]
- Jacobsen, E. N.; Schaus, S. E. "Asymmetric Cycloaddition Reactions,"
U.S. Patent No. 6,130,340 issued 10/10/00.
- Thompson, C. F.; Jamison, T. F.; Jacobsen, E. N. “Total Synthesis of FR901464.
Convergent Assembly of Chiral Components Prepared by Asymmetric
Catalysis,” J. Am. Chem. Soc. 2000, 122,
10482-10483. [pdf]
- Keith, J. M.; Larrow, J. F.; Jacobsen, E. N. “Practical Considerations
in Kinetic Resolution Reactions,” Adv. Synth. & Catal.
2001, 343, 5-26. [pdf]
- Su, J. T.; Vachal, P.; Jacobsen, E. N. “Practical Synthesis of a Soluble
Schiff Base Catalyst for the Asymmetric Strecker Reaction,” Adv.
Synth. & Catal. 2001, 343, 197-200. [pdf]
- Ready, J. M.; Jacobsen, E. N. “Highly Active Oligomeric (salen)Co Catalysts
for Asymmetric Epoxide Ring Opening Reactions,” J. Am. Chem.
Soc. 2001, 123, 2687-2688.
[pdf]
- Jacobsen, E. N.; Schaus, S. E.; Dossetter, A. G.; Jamison, T. F. “Asymmetric
Cycloaddition Reactions,” U.S. Patent #6,211,370 issued 4/3/01.
- Brandes, B. D.; Jacobsen, E. N. “Regioselective Ring Opening of Enantiomerically
Enriched Epoxides via Catalysis with Chiral (Salen)Cr(III) Complexes,”
Synlett 2001, 1013-1015.
- White, M. C.; Doyle, A. G.; Jacobsen, E. N. “Synthetically Useful, Self-Assembling
MMO Mimic System for Catalytic Alkene Epoxidation with Aqueous
H2O2,” J. Am. Chem. Soc. 2001, 123, 7194-7195.
[pdf]
- Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F. “Hydrolytic Kinetic Resolution
of Cyclic Substrates” U.S. Patent No. 6,262,278 B1 issued 7/17/01.
- Chavez, D. E.; Jacobsen, E. N. “Total
Synthesis of Fostriecin (CI-920),” Angew. Chem. Int. Ed.
2001, 40, 3667-3670. [pdf]
- Thompson, C. F.; Jamison, T. F.; Jacobsen, E. N. “FR901464: Total Synthesis,
Proof of Structure, and Evaluation of Synthetic Analogs,” J.
Am. Chem. Soc. 2001, 123, 9974-9983. [pdf]
- Liu, P.; Jacobsen, E. N. “Total Synthesis of
(+)-Ambruticin,” J. Am. Chem. Soc. 2001, 123,
10772-10773. [pdf]
- Jacobsen, E. N., Sigman, M. S. "Parallel
Combinatorial Approach to the Discovery and Optimization of Catalysts
and Uses Thereof," U.S. Patent #6,316,616, issued 11/13/01
- Schaus, S. E.; Brandes, B. D; Larrow, J. F.; Tokunaga, M.; Hansen, K.
B.; Gould, A. E.; Furrow, M. E.; Jacobsen, E. N. “Highly
Selective Hydrolytic Kinetic Resolution of Terminal Epoxides Catalyzed
by Chiral (salen)Cobalt(III)-Complexes. Practical Synthesis of
Enantioenriched Terminal Epoxides and 1,2-Diols,” J.
Am. Chem. Soc. 2002, 124, 1307-1315. [pdf]
- Movassaghi, M.; Jacobsen, E. N. “A Direct Method for the Conversion of
Terminal Epoxides into γ-Butanolides,” J. Am. Chem. Soc.
2002, 124,
2456-2457. [pdf]
- Ruck, R. T.; Jacobsen, E. N. “Asymmetric Catalysis
of Hetero-Ene Reactions with Tridentate Schiff Base Chromium(III)
Complexes,” J. Am. Chem. Soc. 2002, 124,
2882-2883.
[pdf]
- Ready, J. R.; Jacobsen, E. N. “A Practical
Oligomeric (salen)Co Catalyst for Asymmetric Epoxide Ring Opening
Reactions,” Angew. Chem. Int. Ed. 2002, 41,
1374-1377. [pdf]
- Joly, G. D.; Jacobsen,
E. N. “Catalyst-Controlled Diastereoselective Hetero-Diels–Alder
Reactions,” Organic Lett. 2002, 4, 10,
1795-1798. [pdf]
- Jacobsen, E. N.; Schaus, S. E.; Dossetter, A. G.; Jamison, T. F. “Asymmetric
Cycloaddition Reactions,” U.S. Patent #6,369,223 issued 4/9/02.
- Gademann, K.; Chavez, D. E.; Jacobsen, E. N. “Highly Enantioselctive Inverse
Electron Demand Hetero-Diels-Alder Reactions of α,β-Unsaturated
Aldehydes,” Angew. Chem. Int. Ed. 2002, 41,
15, 3059-3061. [pdf]
- Jacobsen, E. N.; Francis, M. B.; Finney, N. S. "Combinatorial Approach for Generating Novel Coordination Complexes," U.S. Patent #6,489,093 issued 12/3/02.
- Vachal, P.; Jacobsen, E. N. “Structure-Based Analysis and Optimization
of a Highly Enantioselective Catalyst for the Strecker Reaction,”
J. Am. Chem. Soc. 2002, 124, 10012-10014. [pdf]
- Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F. “Hydrolytic Kinetic Resolution
of Cyclic Substrates” U.S. Patent # 6,448,414 issued 9/10/02.
- Goodman, S. N.; Jacobsen, E. N. “A Practical Synthesis of α,β-Unsaturated Imides,
Useful Substrates For Asymmetric Conjugate Addition Reactions,”
Adv. Synth. Catal. 2002, 344, 9, 953-956.
[pdf]
- Wenzel, A. G.; Jacobsen, E. N. “Asymmetric Catalytic Mannich Reactions
Catalyzed by Urea Derivatives: Enantioselective Synthesis of β-Aryl-β-Amino
Acids,” J.
Am. Chem. Soc. 2002, 124, 12964-12965. [pdf]
- Movassaghi, M.; Jacobsen,
E. N. “The Simplest ‘Enzyme’,” (Perspective) Science 2002,
298, 1904-1905. [pdf]
- Goodman, S. N.; Jacobsen, E. N. “Enantiopure
β-Hydroxy Morpholine Amides From Terminal Epoxides
via Carbonylation at 1 Atm,” Angew. Chem. Int. Ed. 2002,
41, 4703-4705. [pdf]
- Yoon, T. P.; Jacobsen, E. N. “Privileged Chiral Catalysts,” Science
2003, 299, 1691-1693. [pdf]
- Sammis, G. M.; Jacobsen, E. N. “Highly Enantioselective, Catalytic Conjugate Addition of Cyanide to α,β-Unsaturated Imides,”
J. Am. Chem. Soc. 2003, 125, 4442-4443. [pdf]
- Jacobsen, E. N., Sigman, M. S. "Main Group Metal-Based Asymmetric Catalysts and Applications Thereof," U.S. Patent #6,521,561 issued 2/18/03.
- Chavez, D. E.; Jacobsen, E. N. “Catalyst-Controlled
Inverse Electron Demand Hetero-Diels-Alder Reactions in the Enantio-
and Diastereoselective Synthesis of Iridoid Natural Products,”
Organic Lett. 2003, 5, 2563-2565. [pdf]
- Taylor, M. S.; Jacobsen, E. N. “Enantioselective Michael
Additions to α,β-Unsaturated Imides Catalyzed by a
Salen-Al Complex,” J. Am. Chem. Soc. 2003,
125, 11204-11205. [pdf]
- Wenzel, A. G.; Lalonde, M. P.; Jacobsen, E. N. “Divergent
Stereoinduction Mechanisms in Urea-Catalyzed Additions to Imines,”
Synlett 2003, 12, 1919-1922. [pdf]
- Ruck, R. T.; Jacobsen, E. N. “Asymmetric Hetero-Ene
Reactions of Trimethylsilyl Enol Ethers Catalyzed by Tridentate
Schiff Base Chromium(III) Complexes,” Angew. Chem. Int.
Ed. 2003, 42, 4771-4774. [pdf]
- White, D. E.; Jacobsen, E. N. “New Oligomeric Catalyst
for the Hydrolytic Kinetic Resolution of Terminal Epoxides Under
Solvent-Free Conditions,” Tetrahedron: Asymm.,
2003, 14, 3633-3638. [pdf]
- Vachal, P.; Jacobsen, E. N. "Cyanation of Carbonyl and Imino Groups," in Comprehensive Asymmetric Catalysis (1st Supplement), Jacobsen, E. N.; Pfaltz, A.; Yamamoto, H., Eds.; Springer: New York; 2003; Ch. 28.
- Keith, J. M.; Jacobsen, E. N. “Asymmetric Hydrocyanation of Hydrazones Catalyzed by Lanthanide – PYBOX Complexes,”
Organic Lett. 2004, 6, 153-155. [pdf]
- Raheem, I. T.; Goodman, S. N.; Jacobsen, E. N. “Catalytic
Asymmetric Total Syntheses of Quinine and Quinidine,”
J. Am. Chem. Soc. 2004, 126, 706-707. [pdf]
- Nielsen, L. C. P.; Stevenson, C. P.; Blackmond, D.G.; Jacobsen, E. N. “Mechanistic Investigation Leads to a Synthetic Improvement in the Hydrolytic Kinetic Resolution of Terminal Epoxides, ” J. Am. Chem. Soc. 2004, 126, 1360-1362. [pdf]
An enhanced graphic that represents the rate
of the HKR in three-dimensional space can be found here with
an accompanying text: [animation],
[text]
- Liu, Y.; DiMare, M.; Marchese, S. A.; Jacobsen, E. N.; Jasmin, S. "Hydrolytic Kinetic Resolution of Epoxides," U.S. Patent #6,693,206 issued 2/17/04.
- Joly, G. D.; Jacobsen, E. N. “Thiourea-Catalyzed Enantioselective Hydrophosphonylation of Imines: Practical Access to Enantiomerically Enriched -Amino Phosphonic Acids,“ J. Am. Chem. Soc. 2004, 126,
4102-4103. [pdf]
- Taylor, M. S.; Jacobsen, E. N. "Asymmetric Catalysis in Complex Target Synthesis," Proc. Nat. Acad. Sci. 2004, 101,
5368-5373. [pdf]
- Jacobsen, E. N., Sigman, M. S. “Parallel Combinatorial Approach to the Discovery and Optimization of Catalysts and Uses Thereof,“ U.S. Patent #6,709,824 B2 issued 3/23/04.
- Larrow, J. F.; Jacobsen, E. N. "Asymmetric Processes Catalyzed by Chiral (Salen)Metal Complexes," Topics Organomet. Chem. 2004, 6, 123-152.[pdf]
- Kim, S.; Jacobsen, E. N. "General Catalytic Synthesis of Highly Enantiomerically Enriched Terminal Aziridines from Racemic Epoxides," Angew. Chem. 2004, 43, 3952-3954.[pdf]
- Sammis, G. M.; Danjo, H.; Jacobsen, E. N. "Cooperative Dual Catalysis: Application to the Highly Enantioselective Conjugate Cyanation of Unsaturated Imides," J. Am. Chem. Soc. 2004, 126, 9928-9929.[pdf]
- Taylor, M. S.; Jacobsen, E. N. "Highly Enantioselective Catalytic Acyl-Pictet-Spengler Reactions," J. Am. Chem. Soc. 2004, 126, 10558-10559.[pdf]
- Vanderwal, C. D.; Jacobsen, E. N. "Highly Enantioselective Hydration of α,β-Unsaturated Imides by Al-Catalyzed Conjugate Addition of Oxime Nucleophiles," J. Am. Chem. Soc. 2004, 126, 14724-14725.[pdf]
- Jacobsen, E. N.; Tokunaga, M.; Larrow, J. F. "Hydrolytic Kinetic Resolution of Cyclic Substrates," U.S. Patent #6,800,766 issued 10/5/04.
- Doyle, A. G.; Jacobsen, E. N. “Enantioselective Alkylations of Tributyltin Enolates Catalyzed by Cr(salen)Cl: Access to Enantiomerically Enriched All Carbon Quaternary Centers ,” J. Am. Chem. Soc. 2005, 127, 62-63.
- Yoon, T. P.; Jacobsen, E. N. “Highly Enantioselective Thiourea-catalyzed Nitro-Mannich Reaction,” Angew. Chem. Int. Ed. 2005, 44, 466-468.
- Jacobsen, E. N., Sigman, M. S. "Main Group Metal-Based Asymmetric Catalysts and Applications Thereof," U.S. Patent #6,844,448 issued 1/18/05.
- Taylor, M. S.; Zalatan, D. N.; Lerchner, A. M.; Jacobsen, E. N. “Highly Enantioselective Conjugate Additions to a , b -Unsaturated Ketones Catalyzed by a (salen)Al Complex,” J. Am. Chem. Soc. 2005, 127, 1313-1317.
- Gandelman, M.; Jacobsen, E. N. “Highly Enantioselective Catalytic Conjugate Addition of N-Heterocycles to a , b -Unsaturated Ketones and Imides,” Angew. Chem. Int. Ed. 2005, 44, 2393-2397.
- Wenzel, A. G.; Jacobsen, E. N. “Asymmetric Catalysis in the Enantioselective Synthesis of b -Amino Acids,” in Enantioselective Synthesis of beta-Amino Acids, Juaristi, E.; Soloshonok, V., Eds.; Wiley-VCH: New York, 2005; Chapter 4.
- Fuerst, D. E.; Jacobsen, E. N. “Thiourea-Catalyzed Enantioselective Cyanosilylation of Ketones ,” J. Am. Chem. Soc. 2005, 127, 8964-8965.
- Jarvo, E. R.; Lawrence, B. M.; Jacobsen, E. N. “Highly Enantio- and Regioselective Quinone Diels-Alder Reactions Catalyzed by a Tridentate (Schiff Base)Cr(III) Complex ,” Angew. Chem. Int. Ed. 2005, 44, 6043-6046.
- Boezio, A. A.; Jarvo, E. R.; Lawrence, B. M.; Jacobsen, E. N. “Efficient Total Syntheses of (– )-Colombiasin A and (– )-Elisapterosin B: Application of the Cr-Catalyzed Asymmetric Quinone Diels-Alder Reaction,” Angew. Chem. Int. Ed. 2005, 44, 6046-6050 .
- Taylor, M. S.; Jacobsen, E. N. “Enantioselective Thiourea-Catalyzed Acyl–Mannich Reactions of Isoquinolines,” Angew. Chem. Int. Ed. 2005, 44, 6700-6704 .
- Raheem, I. T.; Jacobsen, E. N. “Highly Enantioselective Aza-Baylis-Hillman Reactions Catalyzed by Chiral Thiourea Derivatives,” Adv. Synth. Catal. 2005, 347, 1701-1708.
- Chavez, D. E.; Jacobsen, E. N. “An Efficient, Highly Diastereo- and Enantioselective Hetero-Diels-Alder Catalyst. Preparation of (2S,6R)-6-(tert-Butyldimethylsilyloxymethyl)-2-Methoxy-2,5-Dihydropyran,” Organic Synth. 2005, 82, 34-42.
- Nielsen, L. P. C. Jacobsen, E. N. “Catalytic, Asymmetric Epoxide Ring-Opening Chemistry,” in Aziridines and Epoxides in Organic Synthesis , Yudin, A., Ed.; Wiley, New York; 2006, Ch. 10.
- Taylor, M. S.; Jacobsen, E. N. “Asymmetric Catalysis by Chiral Hydrogen Bond Donors,” Angew. Chem. Int. Ed. 2006, 45, 1520-1543.
- Balskus, E. P.; Jacobsen, E. N. “a,b -Unsaturated b -Silyl Imide Substrates for Catalytic, Enantioselective Conjugate Additions: A Total Synthesis of (+)-Lactacystin and the Discovery of a New Proteasome Inhibitor ,” J. Am. Chem. Soc. 2006, 128, 6810-6812.
- Huang, H.; Jacobsen, E. N. “Highly Enantioselective Direct Conjugate Addition of Ketones to Nitroalkenes Promoted by A Chiral Primary Amine-Thiourea Catalyst , ” J. Am. Chem. Soc. 2006, 128, 7170-7171.
- Lalonde, M. P.; Chen, Y.; Jacobsen, E. N. “A Chiral Primary Amine-Thiourea Catalyst for the Highly Enantioselective Direct Conjugate Addition of a, a-Disubstituted Aldehydes to Nitroalkenes,” Angew. Chem. Int. Ed. 2006, 45, 6366-6370.
- Stevenson, C. P.; Nielsen, L. P. C. Jacobsen, E. N. “Preparation of (S)-Methyl Glycidate via Hydrolytic Kinetic Resolution,” Org. Synth. 2006, 83, 55, 162-166.
- Yoon, T. P.; Jacobsen, E. N. “Arenecarboxylic Acids,” Science of Synthesis 2006, 20a, 533-549.
- Vanderwal, C. D.; Jacobsen, E. N. “Alk-2-enoic Acids,” Science of Synthesis 2006, 20a, 551-568.
- Yoon, T. P.; Jacobsen, E. N. “Arenecarboxylic Acid Esters,” Science of Synthesis 2006, 20b, 1285-1304.
- Vanderwal, C. D.; Jacobsen, E. N. “Alk-2-enoic Acid Esters,” Science of Synthesis 2006, 20b, 1305-568.
- Tan, K. L.; Jacobsen, E. N. “Indium-Mediated Asymmetric Allylation of Acylhydrazones Using a Chiral Urea Catalyst,” Angew. Chem. Int. Ed. 2007, 46, 1315-1317.
- Doyle, A. G.; Jacobsen, E. N. “Enantioselective Alkylation of Acyclic α, α-Disubstituted Tributyltin Enolates Catalyzed by a {Cr(salen)} Complex,” Angew. Chem. Int. Ed. 2007, 46, 3701-3705.
- Balskus E.P.; Jacobsen, E.N. "Asymmetric Catalysis of the Transannular Diels-Alder Reaction," Science, 2007, 317, 1736-1740.
For either a full-text version or an abstract of this paper, please use the links below:
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