PUBLICATIONS
(click links to download)

1980-1993 | 1994-1998 | 1999-2002 | 2003-2005 | 2006-2010

Studying a Cell Division Amidase Using Defined Peptidoglycan Substrates. T.J. Lupoli, T. Taniguchi, T.S. Wang, D.L. Perlstein, S. Walker, D. Kahne. J Am Chem Soc 2009, 131, 18230-1.

Rapid beta-lactam-induced lysis requires successful assembly of the cell division machinery. H.S. Chung, Z. Yao, N.W. Goehring, R. Kishony, J. Beckwith, D. Kahne. Proc Natl Acad Sci U S A 2009, 106, 21872-7.

Complete Characterization of the Seventeen Step Moenomycin Biosynthetic Pathway. B. Ostash, E.H. Doud, C. Lin, I. Ostash, D.L. Perlstein, S. Fuse, M. Wolpert, D. Kahne, S. Walker. Biochemistry 2009, 48, 8830-41.

Transport of lipopolysaccharide across the cell envelope: the long road of discovery. N. Ruiz, D. Kahne, T.J. Silhavy. Nat Rev Microbiol 2009, 9, 677-83.

Using biological performance similarity to inform disaccharide library design. T. Tanikawa, M. Fridman, W. Zhu, B. Faulk, I.C. Joseph, D. Kahne, B.K. Wagner, P.A. Clemons. J Am Chem Soc 2009, 131, 5075-83.

A Unifying Nitrososynthase Involved in Nitrosugar Biosynthesis. Y. Hu, A. Al-Mestarihi, C.L. Grimes, D. Kahne, B.O. Bachmann, J Am Chem Soc 2008, 130, 15756-7.

Isolated Peptidoglycan Glycosyltransferases from Different Organisms Produce Different Glycan Chain Lengths. T.S. Wang, S.A. Manning, S. Walker, D. Kahne. J Am Chem Soc 2008, 130, 14068-9.

Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. Y. Yuan, S. Fuse, B. Ostash, P. Sliz, D. Kahne, S. Walker. ACS Chem Biol 2008, 3, 429-36.

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. N. Ruiz, L.S. Gronenberg, D. Kahne, T.J. Silhavy. Proc Natl Acad Sci U S A, 2008, 105, 5537-42.

Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. D. Barrett, T.S. Wang, Y. Yuan, Y. Zhang, D. Kahne, S. Walker, J Biol Chem, 2007, 282, 31964-71.

The direction of glycan chain elongation by peptidoglycan glycosyltransferases. D.L. Perlstein, Y. Zhang, T.S. Wang, D.E. Kahne, S. Walker, J Am Chem Soc, 2007, 129, 12674-12675.

Characterization of Rhodosaminyl Transfer by the AknS/AknT Glycosylation Complex and Its Use in Reconstituting the Biosynthetic Pathway of Aclacinomycin A. C. Leimkuhler, M. Fridman, T. Lupoli, S. Walker, C.T. Walsh, D. Kahne, J Am Chem Soc, 2007, 129, 10546-10550.

Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. A.R. Howard-Jones, R.G. Kruger, W. Lu, J. Tao, C. Leimkuhler, D. Kahne D, C.T. Walsh, J Am Chem Soc, 2007, 129, 10082-10083.

Structure and Function of an Essential Component of the Outer Membrane Protein Assembly Machine. S. Kim, J.C. Malinverni, P. Sliz, T.J. Silhavy, S.C. Harrison, D. Kahne, Science, 2007, 317, 961-964.

Chemoenzymatic Formation of Novel Aminocoumarin Antibiotics by the Enzymes CouN1 and CouN7. M. Fridman, C.J. Balibar, T. Lupoli, D. Kahne, C.T. Walsh, S. Garneau-Tsodikova, Biochemistry, 2007, 46, 8462-8471.

Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. J.G. Sklar, T. Wu, L.S. Gronenberg, J.C. Malinverni, D. Kahne, T.J. Silhavy, Proc Natl Acad Sci USA, 2007, 104, 6400-6405.

Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Y. Yuan, D. Barrett, Y. Zhang, D. Kahne, P. Sliz, S. Walker, Proc Natl Acad Sci USA 2007, 104, 5348-5353.

Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. Y. Zhang, E.J. Fechter, T.S. Wang, D. Barrett, S. Walker, D.E. Kahne, J Am Chem Soc 2007, 129, 3080-3081.

The Total Synthesis of Moenomycin A. J.G. Taylor, X. Li, M. Oberthur, W. Zhu, D.E. Kahne, J Am Chem Soc 2006, 128, 15084-15085.

Degradation and Reconstruction of Moenomycin A and Derivatives: Dissecting the Function of the Isoprenoid Chain. M. Adachi, Y. Zhang, C. Leimkuhler, B. Sun, J.V. Latour, D. Kahne, J Am Chem Soc 2006, 128, 14012-14013.

Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2. K. Sakurai, C. Schubert, D. Kahne, J Am Chem Soc. 2006. 128, 11000-11001.

Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. T. Wu, A.C. McCandlish, L.S. Gronenberg, S.S. Chng, T.J. Silhavy, D. Kahne. Proc Natl Acad Sci U S A. 2006. 103, 11754-11759.

Probing the Barrier Function of the Outer Membrane with Chemical Conditionality. N. Ruiz, T. Wu, D. Kahne, T.J. Silhavy, ACS Chem Biol 2006. 1, 385-395.

YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. J.C. Malinverni, J. Werner, S. Kim, J.G. Sklar, D. Kahne, R. Misra, T.J. Silhavy, Mol Microbiol 2006. 61,151-64.

Installation of the Pyrrolyl-2-carboxyl Pharmacophore by CouN1 and CouN7 in the Late Biosynthetic Steps of the Aminocoumarin Antibiotics Clorobiocin and Coumermycin A1. S. Garneau-Tsodikova, A. Stapon, D. Kahne, C.T. Walsh, Biochemistry 2006. 45, 8568-78.

Detection of Bacterial Toxins with Monosaccharide Arrays. M.M. Ngundi, C.R. Taitt, S.A. McMurry, D. Kahne, F.S. Ligler, Biosens Bioelectron. 2006. 21, 1195-1201.

Advances in Understanding Bacterial Outer-membrane Biogenesis. N. Ruiz, D. Kahne, T.J. Silhavy, Nat Rev Microbiol 2006. 4, 57-66.