PUBLICATIONS
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1980 - 1993 | 1994 - 1998 | 1999-2002 | 2003-2008

Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design. Y. Yuan, S. Fuse, B. Ostash, P. Sliz, D. Kahne, S. Walker. ACS Chem Biol 2008, 3, 429-36.

Identification of two inner-membrane proteins required for the transport of lipopolysaccharide to the outer membrane of Escherichia coli. N. Ruiz, L.S. Gronenberg, D. Kahne, T.J. Silhavy. Proc Natl Acad Sci U S A, 2008, 105, 5537-42.

Analysis of glycan polymers produced by peptidoglycan glycosyltransferases. D. Barrett, T.S. Wang, Y. Yuan, Y. Zhang, D. Kahne, S. Walker, J Biol Chem, 2007, 282, 31964-71.

The direction of glycan chain elongation by peptidoglycan glycosyltransferases. D.L. Perlstein, Y. Zhang, T.S. Wang, D.E. Kahne, S. Walker, J Am Chem Soc, 2007, 129, 12674-12675.

Characterization of Rhodosaminyl Transfer by the AknS/AknT Glycosylation Complex and Its Use in Reconstituting the Biosynthetic Pathway of Aclacinomycin A. C. Leimkuhler, M. Fridman, T. Lupoli, S. Walker, C.T. Walsh, D. Kahne, J Am Chem Soc, 2007, 129, 10546-10550.

Kinetic analysis of teicoplanin glycosyltransferases and acyltransferase reveal ordered tailoring of aglycone scaffold to reconstitute mature teicoplanin. A.R. Howard-Jones, R.G. Kruger, W. Lu, J. Tao, C. Leimkuhler, D. Kahne D, C.T. Walsh, J Am Chem Soc, 2007, 129, 10082-10083.

Structure and Function of an Essential Component of the Outer Membrane Protein Assembly Machine. S. Kim, J.C. Malinverni, P. Sliz, T.J. Silhavy, S.C. Harrison, D. Kahne, Science, 2007, 317, 961-964.

Chemoenzymatic Formation of Novel Aminocoumarin Antibiotics by the Enzymes CouN1 and CouN7. M. Fridman, C.J. Balibar, T. Lupoli, D. Kahne, C.T. Walsh, S. Garneau-Tsodikova, Biochemistry, 2007, 46, 8462-8471.

Lipoprotein SmpA is a component of the YaeT complex that assembles outer membrane proteins in Escherichia coli. J.G. Sklar, T. Wu, L.S. Gronenberg, J.C. Malinverni, D. Kahne, T.J. Silhavy, Proc Natl Acad Sci USA, 2007, 104, 6400-6405.

Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis. Y. Yuan, D. Barrett, Y. Zhang, D. Kahne, P. Sliz, S. Walker, Proc Natl Acad Sci USA 2007, 104, 5348-5353.

Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases. Y. Zhang, E.J. Fechter, T.S. Wang, D. Barrett, S. Walker, D.E. Kahne, J Am Chem Soc 2007, 129, 3080-3081.

The Total Synthesis of Moenomycin A. J.G. Taylor, X. Li, M. Oberthur, W. Zhu, D.E. Kahne, J Am Chem Soc 2006, 128, 15084-15085.

Degradation and Reconstruction of Moenomycin A and Derivatives: Dissecting the Function of the Isoprenoid Chain. M. Adachi, Y. Zhang, C. Leimkuhler, B. Sun, J.V. Latour, D. Kahne, J Am Chem Soc 2006, 128, 14012-14013.

Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2. K. Sakurai, C. Schubert, D. Kahne, J Am Chem Soc. 2006. 128, 11000-11001.

Identification of a protein complex that assembles lipopolysaccharide in the outer membrane of Escherichia coli. T. Wu, A.C. McCandlish, L.S. Gronenberg, S.S. Chng, T.J. Silhavy, D. Kahne. Proc Natl Acad Sci U S A. 2006. 103, 11754-11759.

Probing the Barrier Function of the Outer Membrane with Chemical Conditionality. N. Ruiz, T. Wu, D. Kahne, T.J. Silhavy, ACS Chem Biol 2006. 1, 385-395.

YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. J.C. Malinverni, J. Werner, S. Kim, J.G. Sklar, D. Kahne, R. Misra, T.J. Silhavy, Mol Microbiol 2006. 61,151-64.

Installation of the Pyrrolyl-2-carboxyl Pharmacophore by CouN1 and CouN7 in the Late Biosynthetic Steps of the Aminocoumarin Antibiotics Clorobiocin and Coumermycin A1. S. Garneau-Tsodikova, A. Stapon, D. Kahne, C.T. Walsh, Biochemistry 2006. 45, 8568-78.

Detection of Bacterial Toxins with Monosaccharide Arrays. M.M. Ngundi, C.R. Taitt, S.A. McMurry, D. Kahne, F.S. Ligler, Biosens Bioelectron. 2006. 21, 1195-1201.

Advances in Understanding Bacterial Outer-membrane Biogenesis. N. Ruiz, D. Kahne, T.J. Silhavy, Nat Rev Microbiol 2006. 4, 57-66.

In Vitro Reconstitution of EryCIII Activity for the Preparation of Unnatural Macrolides. Y. Yuan, H.S. Chung, C. Leimkuhler, C.T. Walsh, D. Kahne, S. Walker, J Am Chem Soc 2005, 127, 14128-14129.

A Systematic Investigation of the Synthetic Utility of Glycopeptide Glycosyltransferases. M. Oberthür, C. Leimkuhler, R.G. Kruger, W. Lu, C.T. Walsh, D. Kahne, J. Am. Chem. Soc. 2005 127, 10747-10752.

AknT Is an Activating Protein for the Glycosyltransferase AknS in L-Aminodeoxysugar Transfer to the Aglycone of Aclacinomycin A. W. Lu, C. Leimkuhler, G.J. Gatto Jr., R.G. Kruger, M. Oberthür, D. Kahne, C.T. Walsh, Chem Biol. 2005, 12(5), 527-534.

Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. E. Kagan, G. Ragupathi, S.S. Yi, C.A. Reis, J. Gildersleeve, D. Kahne, H. Clausen, S.J. Danishefsky, P.O. Livingston. Cancer Immunol. Immunother. 2005, 54(5), 424-430.

Characterization of the Aminocoumarin Ligase SimL from the Simocyclinone Pathway and Tandem Incubation with NovM,P,N from the Novobiocin Pathway. M. Pacholec, C.L. Freel Meyers, M. Oberthür, D. Kahne, C.T. Walsh, Biochemistry 2005. 44, 4949-4956.

Kinetic Characterization of the Glycosyltransferase Module of Stahylococcus aureus PBP2. D. Barrett, C. Leimkuhler, L. Chen, D. Walker, D. Kahne, and S. Walker, J Bacteriol 2005 187(6):2215-7.

Tailoring of Glycopeptide Scaffolds by the Acyltransferases from the Teicoplanin and A-40,926 Biosynthetic Operons. R. Kruger, W. Lu, M. Oberthür, J. Tao, D. Kahne, and C. T. Walsh, Chem. Biol. 2005, 12, 131-140.

Glycopeptide and Lipoglycopeptide Antibiotics. D. Kahne, C. Leimkuhler, W. Lu, C.T. Walsh, Chem. Rev. 2005, 105, 425-448.

Glycosylation of Glycopeptides: A Comparison of Chemoenzymatic and Chemical Methods. C. Leimkuhler, Z. Chen, R. Kruger, M. Oberthür, W. Lu, C. T. Walsh, and D. Kahne, Tetrahedron: Asymmetry 2005,16, 599-603.

Chemical Conditionality: A Genetic Strategy to Probe Organelle Assesmbly. N. Ruiz, B. Falcone, D. Kahne, and T. J. Silhavy, Cell 2005 121, 307-317.

Identification of a Multi-Component Complex Required for Outer Membrane Biogenesis in Escerichia coli. T. Wu, J. Malinverni, N. Ruiz, S. Kim, T. J. Silhavy, and D. Kahne, Cell 2005 121, 235-245.

Differential Inhibition of S. aureus PBP2 by Glycopeptide Antibiotics. C. Leimkuhler, L. Chen, D. Barrett, G. Panzone, B. Sun, B. Falcone, M. Oberthür, S. Donadio, S. Walker, and D. Kahne, J. Am. Chem. Soc. 2005 127(10):3250-1.

Assembly of Dimeric Variants of Coumermycins by Tandem Action of the Four Biosynthetic Enzymes CouL, CouM, CouP and NovN. C. L. Freel Meyers, M. Oberthür, L. Heide, D. Kahne and C. T. Walsh, Biochemistry 2004 43, 15022-15036.

Use of a Retroinverso p53 Peptide as an Inhibitor of MDM2. K. Sakurai, H. S. Chung, and D. Kahne, J. Am. Chem. Soc.2004, 126, 16288-16289.

Comparison of antigen constructs and carrier molecules for augmenting the immunogenicity of the monosaccharide epithelial cancer antigen Tn. E. Kagan, G. Ragupathi, S. Yi, C. Reis, J. Gildersleeve, D. Kahne, H. Clausen, S. Danishefsky, and P. Livingston, Cancer Immunology, Immunotherapy, Springer-Verlag Heidelberg 2004

A Practical Method for the Stereoselective Generation of beta-2-Deoxy Glycosyl Phosphates. M. Oberthür, C. Leimkuhler and D. Kahne, Org. Lett. 2004, 6, 2873-2876.

Reconstitution and Characterization of a New Desosaminyl Transferase, EryCIII, from the Erythromycin Biosynthetic Pathway. H. Lee, H. S. Chung, C. Hang, C. Koshla, C. T. Walsh, D. Kahne and S. Walker, J. Am. Chem. Soc. 2004, 126, 9924-9925.

Characterization of NovP and NovN: Completion of Novobiocin Biosynthesis by Sequential Tailoring of the Noviosyl Ring. C. L. Freel Meyers, M. Oberthür, H. Xu, L. Heide, D. Kahne and C. T. Walsh, Angewandte Chemie Int. Ed. 2004, 43, 67-70.

Stochlastic Detection of Monovalent and Bivalent Protein-Ligand Interactions. S. Howorka, J. Nam, H. Bayley and D. Kahne, Angewandte Chemie Int. Ed. 2004, 43, 842-846.

Characterization of a Regiospecific Epivancosaminyl Transferase GtfA and Enzymatic Reconstruction of the Antibiotic Chloroeremomycin. W. Lu, M. Oberthur, C. Leimkuhler, J. Tao, D. Kahne and C. T.  Walsh, Proc. Natl Acad. Sci. USA 2004, 101, 4390-4395.

AknK Is an L-2-Deoxyfucosyltransferase in the Biosynthesis of the Anthracycline Aclacinomycin A. W. Lu, C. Leimkuhler, M. Oberthür, D. Kahne and C. T. Walsh, Biochemistry 2004, 43, 4548-4558.

Vancomycin Analogs Active Against VanA-Resistant Strains Inhibit Bacterial Transglycosylase Without Binding Substrate. L. Chen, D. Walker, B. Sun, Y. Hu, S. Walker and D. Kahne. Proc. Natl. Acad. Sci. USA 2003, 100, 5658-5663.

Initial Characterization of Novobiocic Acid Noviosyl Transferase Activity of NovM in Biosynthesis of the Antibiotic Novobiocin. C. L. Freel Meyers, M. Oberthür, J. Anderson, D. Kahne and C. T. Walsh, Biochemistry 2003, 42, 4179-4189.

Overcoming Degeneracy in Carbohydrate Recognition. A. Basu and D. Kahne, Angewandte Chemie Int. Ed. 2003, 42,2504-2506.