Selected Publications (Since 1998)
click to view as PDF

 

"Late-stage polyribitol phosphate wall teichoic acid biosynthesis in Staphylococcus aureus." Meredith TC, Swoboda JG, Walker S. J Bacteriol 2008;190:3046-56.

"A strategy to discover inhibitors of O-linked glycosylation" Gross BJ, Swoboda JG, Walker S. J Am Chem Soc 2008; 130:440-1.

"A Revised Pathway Proposed for Staphylococcus aureus Wall Teichoic Acid Biosynthesis Based on In Vitro Reconstitution of the Intracellular Steps" Brown S, Zhang YH, and Walker S. Chemistry and Biology 2008; 15:12-21.

"Analysis of glycan polymers produced by peptidoglycan glycosyltransferases" Barrett D, Wang TS, Yuan Y, Zhang Y, Kahne D, and Walker S. J Biol Chem 2007; 282:31964-71.

"The direction of glycan chain elongation by peptidoglycan glycosyltransferases" Perlstein DL, Zhang Y, Wang TS, Kahne DE, and Walker S. J Am Chem Soc 2007; 129:12674-12675.

"Characterization of Rhodosaminyl Transfer by the AknS/AknT Glycosylation Complex and Its Use in Reconstituting the Biosynthetic Pathway of Aclacinomycin A" Leimkuhler C, Fridman M, Lupoli T, Walker S, Walsh CT, and Kahne D. J Am Chem Soc, 2007; 129:10546-10550.

"O-linked N-acetylglucosaminyltransferase inhibition prevents G2/M transition in Xenopus laevis oocytes" Dehennaut V, Lefebvre T, Sellier C, Leroy Y, Gross B, Walker S, Cacan R, Michalski JC, Vilain JP, and Bodart JF. J Biol Chem, 2007; 282:12527-12536.

"Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis" Yuan Y, Barrett D, Zhang Y, Kahne D, Sliz P, and Walker S. Proc Natl Acad Sci USA, 2007; 104:5348-5353.

"Synthesis of heptaprenyl-lipid IV to analyze peptidoglycan glycosyltransferases" Zhang Y, Fechter EJ, Wang TS, Barrett D, Walker S, and Kahne DE. J Am Chem Soc, 2007;129:3080-3081.

"A Streamlined Metabolic Pathway for the Biosynthesis of Moenomycin A" Ostash B, Saghatelian A, and Walker S. Chemistry and Biology, 2007;14:257-267.

"Acceptor Substrate Selectivity and Kinetic Mechanism of Bacillus subtilis TagA" Zhang Y, Ginsberg C, Yuan Y, and Walker S. Biochemistry, 2006;36:10895-10904.

"Imaging Peptidoglycan Biosynthesis in Bacillus subtilis with Fluorescent Antibiotics" Tiyanont K, Doan T, Lazarus MB, Fang X. Rudner DZ, and Walker S. Proc. Natl. Acad. Sci. USA, 2006;103:11033-11038.

"In Vitro Reconstitution of Two Essential Steps in Wall Teichoic Acid Biosynthesis" Ginsberg C, Zhang Y, Yuan Y, and Walker S. ACS Chemical Biology, 2006;1:25-28.

"The Mechanism of Action of Ramoplanin and Enduracidin" Fang X, Tiyanont K, Zhang Y, Boger D, and Walker S. Molecular Biosystems, 2006;2:69-76.

"Enabling Glycosyltransferase Evolution: A Facile Substrate-attachment Strategy for Phage-display Enzyme Evolution" Love KR, Swoboda JG, Noren CJ, and Walker S. Chem BioChem, 2006;7:753-756.

"Discovery of O-GlcNAc Transferase Inhibitors" Gross BJ, Kraybill BC, and Walker S. J Am Chem Soc 2005; 127:14588-14589.

"In Vitro Reconstitution of EryCIII Activity for the Preparation of Unnatural Macrolides" Yuan Y, Chung HS, Leimkuhler C, Walsh CT, Kahne D, and Walker S. J Am Chem Soc 2005;127:14128-14129.

"Bacterial Transglycosylase Inhibitors" Ostash B and Walker S. Curr Opin Chem Biol 2005;9:459-466.

"Differential Inhibition of S. aureus PBP2 by Glycopeptide Antibiotics" Leimkuhler C, Chen L, Barrett D, Panzone G, Sun B, Falcone B, Donadio S, Walker S, Kahne D.J. Am. Chem. Soc. 2005;127:3250-3251.

"Chemistry and Biology of Ramoplanin: a Lipoglycodepsipeptide with Potent Antibiotic Activity" Walker S, Hu Y, Chen L, Rew Y, Shin D, and Boger DL, Chem. Rev. 2005;105:425-448.

"Kinetic Characterization of the Glycosyltransferase Module of Stahylococcus aureus PBP2" Barrett D, Leimkuhler C, Chen L, Walker D, Kahne D, Walker S. J. Bacteriol. 2005;187:2215-2217.

"Synthesis of mono- and disaccharide analogs of moenomycin and lipid II for inhibition of transglycosylase activity of penicillin-binding protein 1b" Garneau S, Qiao L, Chen L, Walker S, Vederas JC. Bioorg. Med. Chem. 2004; 12:6473-6494.

"Expression and Characterization of the Isolated Glycosyltransferase Module of E. coli PBP1b" Barrett DS, Chen L, Litterman N, Walker S. Biochemistry 2004; 43:12375-12381.

"Reconstitution and Characterization of a New Desosaminyl Transferase, EryCIII, from the Erythromycin Biosynthetic Pathway" Lee HY, Chung HS, Hang C, Khosla C, Walsh CT, Kahne D, Walker S. J. Am. Chem. Soc. 2004; 126:9924-9925.

"Dissecting Ramoplanin: Mechanistic Analysis of Synthetic Ramoplanin Analogues as a Guide to the Design of Improved Antibiotics" Chen L, Yuan Y, Helm JS, Hu Y, Rew Y, Shin D, Boger DL, Walker S. J. Am. Chem. Soc. 2004; 126:7462-7463.

"Identification of Selective Inhibitors of the Glycosyltransferase MurG via High-Throughput Screening" Helm J, Hu Y, Chen L, Ginsberg D, Gross B, Kraybill B, Tiyanont D, Fang X, Wu T, Walker S. Chem. & Biol. 2004; 11:703-711.

"Ramoplanin Inhibits Bacterial Transglycosylases by Binding as a Dimer to Lipid II" Hu Y, Helm JS, Chen L, Ye X-Y, Walker S. J. Am. Chem. Soc. 2003; 125:8736-8737.

"Identification of Active Site Inhibitors of MurG Using a Generalizable High-Throughput Glycosyltransferase Screen" Helm JS, Hu Y, Chen L, Gross B, Walker S, J. Am. Chem. Soc. 2003; 125:11168-11169.

"Vancomycin Analogs Active Against VanA Strains Inhibit Bacterial Transglycosylase Without Binding Substrate" Chen L, Walker D, Sun B, Hu Y, Walker S, Kahne D. Proc. Natl. Acad. Sci. USA, 2003; 100:5658-5663.

"Lipid II is an Intrinsic Component of the Pore Induced by Nisin in Bacterial Membranes" Breukink E, van Heusden HE, Vollmerhaus PJ, Swiezewska E, Brunner L, Walker S, Heck AJ, de Kruijff B, J. Biol. Chem. 2003; 278:19898-19903.

"Crystal Structure of the MurG: UDP-GlcNAc Complex Reveals Common Structural Principles of a Superfamily of Glycosyltransferases" Hu Y, Chen L, Ha S, Gross B, Falcone B, Walker D, Mokhtarzadeh M, Walker S. Proc. Natl. Acad. Sci. USA 2003; 100:845-849.

"Rethinking Ramoplanin: The Role of Substrate Binding in Inhibition of Peptidogylcan Biosynthesis" Helm J, Chen L, Walker S. J. Am. Chem. Soc. 2002; 124:13970-13971.

"Intrinsic Lipid Preferences and Kinetic Mechanism of Escherichia coli MurG" Chen L, Men H, Ha S, Ye X-Y, Brunner L, Hu Y, and Walker S. Biochemistry, 2002; 41:6824-6833.

"A New Structure for the Substrate-Binding Antibiotic Ramoplanin" Lo M, Helm JS, Sarngadharan G, Pelczer I, Walker S. J. Am. Chem. Soc. 2001; 123:8640-8641.

"Better Substrates for Bacterial Transglycosylases" Ye X-Y, Lo M, Brunner L, Walker D, Kahne D, Walker S. J. Am. Chem. Soc. 2001;123:3155-3116.

"The 1.9 Å crystal structure of E. coli MurG, a membrane-associated glycosyltransferase involved in peptidoglycan biosynthesis" Ha S, Walker D, Shi Y, Walker S. Protein Science 2000;9:1045-1052.

"A New Mechanism of Action Proposed for Ramoplanin" Lo M, Men H, Branstrom A, Helm J, Yao N, Goldman R, Walker S. J. Am. Chem. Soc.2000;122:3540-3541.

"The Kinetic Characterization of Escherichia coli MurG Using Synthetic Substrate Analogues" Ha S, Chang E, Lo M, Men H, Park P, Ge M, Walker S. J. Am. Chem. Soc. 1999;121:8415-8426.

"Substrate Synthesis and Activity Assay for MurG" Men H, Park P, Ge M, Walker S. J. Am. Chem. Soc. 1998;120:2484-2485.