Peptidoglycan
Biosynthesis:
- Enzymology
- Cell Biology
Teichoic Acids
Antibiotics
OGT

Research Interests

The Walker group primarily studies metabolic pathways involved in microbial survival and pathogenesis. The underlying motivation for many of the projects is to develop the scientific and technological foundations for the discovery and evaluation of new targets, strategies, and compounds to treat resistant bacterial infections.

Approaches

Chemical Biology: the use of organic and biophysical chemistry, enzymology, molecular genetics, and cell biology to study fundamental metabolic pathways and to develop strategies to manipulate or inhibit them within the cellular context.

Click on Each Subheading for Further information:

 

Enzymology and Inhibition of Peptidoglycan Biosynthesis

Temporal and Spatial Organization of Peptidolycan Biosynthesis

Wall Teichoic Acid Biosynthesis: A New Target for Antimicrobial Intervention?

Antibiotic Mechanisms and Biosynthesis

Small Molecule-Based Approaches to Dissecting the Biological Functions of OGT