M.-Christina White

Work:

Department of Chemistry & Chemical Biology
Harvard University
12 Oxford Street
Cambridge, MA 02138
Tel: (617) 496-0750
email: white@chemistry.harvard.edu

 

Home:

1 Dana Street
Cambridge, MA 02138

Personal:

Name: Maria-Christina White
Born: April 27, 1971. Athens, Greece.
Citizenship: USA
Marital Status: Married. No children.

  
Research Interests
 

The discovery of new transition metal-mediated reactions that address unsolved problems in synthetic methodology. The development of these reactions into efficient, selective catalytic methods that will find widespread use in organic synthesis.

Education  
1999-2002

National Institutes of Health Postdoctoral Fellow
Harvard University, Department of Chemistry, Cambridge , Massachusetts
Research advisor: Professor Eric N. Jacobsen
Development of a synthetically useful MMO mimic system for epoxidation.

1994-1998

American Chemical Society Predoctoral Fellow
Johns Hopkins University, Department of Chemistry, Baltimore, Maryland.
Degree awarded: Ph.D.
Research advisor: Professor Gary H. Posner
Thesis title: Antiproliferative/Anti-Calcemic Hybrid Analogs of the Hormone
1a ,25-Dihydroxyvitamin D3: Design, Synthesis and Biological Evaluation.

1992-1993

Johns Hopkins University, Department of Biology, Baltimore, Maryland.
Research advisor: Professor Christian B. Anfinsen.
Development of a biodegradation protocol using hyperthermophilic bacteria.

1988-1992

Smith College, Northhampton, Massachusetts.
Degree awarded: B.A. with Highest Honors in Biochemistry, cum laude.
Research advisor (1991-1992): Professor Stuart Rosenfeld
Thesis title: Attempted Synthesis of 2,13-diaza-6,11-dioxa[14](9,10) anthracenophane: An Anthraceno-Cryptand Host.

Awards and Honors

·

National Institutes of Health Postdoctoral Fellowship (1999-2002)

·
 American Chemical Society, Division of Medicinal Chemistry Predoctoral Fellowship (1997-1998)
·
 Sarah and Adolph Roseman Award for Outstanding Achievement in Chemistry, JHU (1997)
·
 Sigma Xi, Smith College (1992)
·
 First Group Scholar, Smith College (1992)
·
 Ford Foundation Summer Research Grant, Smith College (1991)
·
 Dean's List, Smith College (1988-1992)
Teaching  
 

·

 Spring Term 2000
Instructor

Harvard University, Department of Chemistry
Chemistry 135: Experimental Synthetic Chemistry
Introduction to modern experimental organic chemistry and spectroscopy. Independently prepared and gave a series of one
hour lectures on modern organic spectroscopic methods. Wrote and administered mid-term and final exams. Consulted on laboratory projects. (see course lecture notes and Harvard course guide class evaluation).

·
 Fall Term 2000
Guest Instructor

Harvard University, Department of Chemistry
Chemistry 30: Organic Chemistry
Gave two lectures: Introduction to Pericyclic Reactions, The Diels-Alder Reaction

·
 Fall Term 1994
Spring Term 1995
Teaching Fellow

Johns Hopkins University, Department of Chemistry
Introductory Organic Chemistry (030.104)
Taught a one hour section once a week covering course
material. Graded exams.

·
 Spring Term 1994
Teaching Fellow

Johns Hopkins University, Department of Biology
Cell Biology (020.306)
Taught a four hour lab once a week that reinforced class topics. Graded exams.

·
 Fall Term 1993
Teaching Fellow

Johns Hopkins University, Department of Biology
Biochemistry (020.305)
Taught a four hour lab once a week that reinforced class topics. Graded exams.

Publications


Papers

  1. White, M.C.; Anfinsen, C.B. "Biodegradation of Mustard Gas Hydrolysis Product, Thiodiglycol, by Cells and Their Sonocates of the Hyperthermophilic Bacterium Pyrococcus Furiosus." Proceedings of the 1992 ERDEC Scientific Conference on Chemical Defense Research, 1993, 455-458.

  2. Posner, G.H.; White, M.C.; Dolan, P.; Kensler, T.W.; Yukihiro, S.; Guggino, S.E. "1 a,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural Changes at Both the A-Ring and the C,D-Ring Side-Chain." Bioorg. Med. Chem. Lett. 1994, 4, 2919-2924. * see: Chem. & Eng. News 2001, 78, 29.

  3. Posner, G.H.; Li, Z.; White, M.C., Vinader, V.; Takeuchi, K.; Guggino, S.E.; Dolan, P.; Kensler, T.W. "1a ,25-Dihydroxyvitamin D3 Analogs Featuring Aromatic and Heteroaromatic Rings: Design, Synthesis, and Preliminary Biological Testing." J. Med. Chem. 1995, 38, 4529-4537.

  4. Peleg, S.; Lui, Y.-Y.; Reddy, S.; Horst, R.L.; White, M.C.; Posner, G.H. "A 20-Epi Side Chain Restores Growth-Regulatory and Transcriptional Activities of an A Ring-Modified Hybrid Analog of 1a ,25-Dihydroxyvitamin D3 Without Increasing its Affinity to the Vitamin D Receptor." Journal of Cellular Biochemistry, 1996, 63, 149.

  5. Posner, G.H.; Lee, J.K.; White, M.C., Hutchings, R.H.; Dai, H., Dolan, P.; Kensler, T.W. "Antiproliferative Hybrid Analogs of the Hormone 1a ,25-Dihydroxyvitamin D3: Design, Synthesis, and Preliminary Biological Evaluation." J. Org. Chem. 1997, 62, 3299-3314.

  6. Boyan, B.D.; Posner, G.H.; Greising, D.M.; White, M.C.; Sylvia, V.L.; Dean, D.D.; Schwartz, Z. "Structural Analogues of 1,25-(OH)2D3 Regulate Chondrocyte Proliferation and Proteoglycan Production as well as Protein Kinase C Through a Nongenomic Pathway." J. of Cellular Biochemistry 1997, 66, 1-14.

  7. White, M.C.; Burke, M.D.; Peleg, S.; Brem, H.; Posner, G.H. "Conformationally Restricted Hybrid Analogues of the Hormone 1a ,25-Dihydroxyvitamin D3: Design, Synthesis, and Biological Evaluation." Bioorg. Med. Chem. 2001, 9, 1691-1699.

  8. White, M.C.; Doyle, A.G.; Jacobsen, E.N. "A Synthetically Useful, Self-Assembling MMO Mimic System for Catalytic Alkene Epoxidation with Aqueous H2O2." J. Am. Chem. Soc. 2001, 123, 7194-7195. * see: Chem. & Eng. News 2001, 79, 9; Chem. & Eng. News Highlights 2001, 79, 51.

Patents

  1. Posner, G.H.; White, M.C. "Vitamin D3 Analogues." U.S. Patent. No. 849-716, 1995, 24 pp.

  2. Burke, M.; White, M.C.; Lee, J.K.; Watts, M.; Tyler, B.; Posner, G.H.; Brem, H. "Controlled Release Vitamin D3 Derivative Formulations for Treatment of Cancer." Provisional Patent JHU Ref.: DM-3301, filed September 2, 1997.


Reviews

  1. White, M.C.; Posner, G.H. "Thermally-Induced One-Step Construction of the Tetracyclic Steroidal Skeleton from Acyclic Enynes-Allenes.": Andemichael, Y.W.; Huang, Y.; Wang, K.K. condensation and commentary; Chemtracts-Organic Chemistry, 1993, 296-299.

  2. White, M.C.; Posner, G.H. "A Highly Stereoselective Optical Switching Process Based on Donor-Acceptor Substituted Dissymmetric Alkenes.": Jager, W.F.; de Jong, J.C.; de Lange, B.; Huck, N.P.M., Meetsma, A.; Feringa, B.L. condensation and commentary" Chemtracts-Organic Chemistry, 1995, 295-299.


Abstracts

  1. Liu, Y.-Y.; Reddy, S; Posner, G.H.; White, M.C.; Li, Z.; Lee, J.K.; Peleg, S. "Side Chains With 20-Epi Configuration Restore Vitamin D Receptor-Mediated Transcriptional Activity of 1b -Hydroxymethyl Analogs of 1 ,25-Dihydroxyvitamin D3." J. of Bone and Mineral Research: Program and Abstracts 1995, 10, S292.

  2. Posner, G.H.; White, M.C.; Peleg, S. "1a ,25-Dihydroxyvitamin D3 Hybrid Analogs with Structural Changes at Both the A-Ring and C,D-Ring Side Chain." Presented at the 4th Annual Brown Symposium On Vitamin D, Providence, Rhode Island, September 12-14, 1996.

  3. Burke, M.D.; White, M.C.; Watts, M.C.; Lee, J.K.; Tyler, B.M.; Posner, G.H.; Brem, H. "Hybrid Analogs of 1a ,25-Dihydroxyvitamin D3 Having Potent Antiproliferative Effects Against Murine Tumor Cell Lines Metastatic to the Brain." In Vitamin D3: Chemistry, Biology and Clinical Applications of the Steroid Hormone; Proceedings of theTenth Workshop On Vitamin D; Norman, A.W.; Bouillon, R.; Thomasset, M., Eds.; University of California Press, 1997, pp 487.

  4. Schwartz, Z.; Posner, G.H.; White, M.C.; Greising, D.M.; Sylvia, V.L.; Dean, D.D. "Hybrid Analogues of 1a ,25-(OH)2D3 Modified on Both the A Ring and C,D-Ring Side Chain Elicit Rapid Membrane-Mediated Effects on Chondrocytes" In Vitamin D3: Chemistry, Biology and Clinical Applications of the Steroid Hormone; Proceedings of theTenth Workshop On Vitamin D ; Norman, A.W.; Bouillon, R.; Thomasset, M., Eds.; University of California Press, 1997, pp 381.

  5. Burke, M.; White, M.C.; Lee, J.K.; Watts, M.; Tyler, B.; Posner, G.H.; Brem, H. "Biodegradable Polymer Wafers Impregnated with Hybrid Analogs of 1 ,25-Dihydroxyvitamin D3 for Treatment of Intracranial Metastases." Presented at the 5th Annual Brown Symposium On Vitamin D, Providence, Rhode Island, September 7-9, 1997.

  6. Posner, G.H.; White, M.C. "Conformationally Restricted Hybrid Analogs of 1a,25-Dihydroxyvitamin D3."Presented at the 216th National Meeting of the American Chemical Society, Boston, Massachussetts, August 28, 1998.

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