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Elias J. Corey
Research
in the Corey group spans a number of areas of experimental organic and
bioorganic chemistry and also includes a program on the application of
computers to organic problems. The total synthesis of a wide range of
complex structures is the central research activity. Many of these molecules
are rare substances, available in only trace quantities from natural sources.
Investigations directed toward new methods and strategies for the construction
of complex molecules are an important part of the group effort. There
is a growing emphasis on the rational development of sophisticated enzyme-like
catalysts (molecular robots) for synthetic organic reactions.
In the bioorganic area a number of collaborative
studies are underway involving diverse disease states including arthritis,
asthma, autoimmune, cardiovascular disease, and AIDS, and have as a common
denominator the understanding of disease mechanisms at the molecular level.
Work in this area is also concerned with the design and synthesis of new,
totally artificial biologically active molecules and with mechanisms of
biosynthesis and immunochemical regulation.
Computer research involves the development of
general problem-solving programs for organic syntheses and computer graphics.
Selected Publications
1. "The Logic of Chemical Synthesis: Multistep Synthesis
of Complex Carbogenic Molecules (Nobel Lecture)," E.J. Corey, Angew.
Chem. Int. Ed. Engl., 30, 455 (1991).
2. "The Origin of Greater Than 200 : 1 Enantioselectivity
in a Catalytic Diels-Alder Reaction as Revealed by Physical and Chemical
Studies," E.J. Corey, T.-P. Loh, T.D. Roper, M.D. Azimioara, and M.C.
Noe, J. Am. Chem. Soc., 114, 8290 (1992).
3. "Total Synthesis of Lactacystin," E.J. Corey
and G.A. Reichard, J. Am. Chem. Soc., 114, 10677 (1992).
4. "Enantioselective Total Synthesis of Miroestrol,"
E.J. Corey and L.I. Wu, J. Am. Chem. Soc., 115, 9327 (1993).
5. "Rigid and Highly Enantioselective Catalyst
for the Dihydroxylation of Olefins Using Osmium Tetraoxide Clarifies the
Origin of Enantiospecificity," E.J. Corey and M.C. Noe, J. Am. Chem.
Soc., 115, 12579 (1993).
6. "Molecular cloning, characterization, and overexpression
of ERG7, the Saccharomyces cerevisiae gene encoding lanosterol synthase,"
E.J. Corey, S.P.T. Matsuda, and B. Bartel, Proc. Natl. Acad. Sci. USA,
91, 2211 (1994).
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