Organic Synthesis

14. Enantioselective Synthesis of the Central Ring System of Lomaiviticin A in the Form of an Unusually Stable Cyclic Hydrate. Krygowski, E. S.; Murphy-Benenato, K.; Shair, M. D. Angew. Chem. Int. Ed. Engl. 2008, 47, 1680-1684. pdf

13. Syntheses of the Eastern Halves of Ritterazines B, F, G, and H, Leading to Reassignment of the 5,5-Spiroketal Stereochemistry of Ritterazines B and F. Phillips, S. T.; Shair, M. D. J. Am. Chem. Soc. 2007, 129, 6589-6598. pdf

12. Stereoelectronic Effects Dictate Mechanistic Dichotomy between Cu(II)-Catalyzed and Enzyme-Catalyzed Reactions of Malonic Acid Half Thioesters. Fortner, K. C.; Shair, M. D. J. Am. Chem. Soc. 2007, 129, 1032-1033. pdf

11.  Catalytic Enantioselective Thioester Aldol Reactions That Are Compatible With Protic Functional Groups.  Magdziak, D.; Lalic, G.; Lee, H. M.;  Fortner, K. C.; Aloise, A. D.; Shair, M. D.  J. Am. Chem. Soc. 2005, 127, 7284-7285. pdf

10.  Dynamic Kinetic Resolution During a Cascade Reaction on Substrates with Chrial All-Carbon Quaternary Centers.  Xu, K.; Lalic, G.; Shair, M. D. Angew. Chem. Int. Ed. Engl. 2005, 44, 2259-2261. pdf

9.  Synthesis of (-)-longithorone A:  Using Organic Synthesis to Probe a Proposed Biosynthesis.  Morales, C. A.; Layton, M. E.; Shair, M. D.  Proc. Natl. Acad. Sci. 2004, 101, 33, 12036-12041. pdf

8. An Exceptionally Mild Catalytic Thioester Aldol Reaction Inspired by PolyketideBiosynthesis.  Lalic, G; Aloise, A. D.; Shair, M. D. J. Am. Chem. Soc. 2003, 125, 2852-2853. pdf

7. Biomimetic Synthesis of (-)-Longithorone A.  Layton, M. E.; Morales, C. M.; Shair, M. D. J. Am. Chem. Soc. 2002, 124, 773-775. pdf

6. Reaction Microarrays:  A Method for Determining the Enantiomeric Excess of Thousands of Samples.  Korbel, G.; Lalic, G.; Shair, M. D.  J. Am. Chem. Soc. 2001, 123, 361-362. pdf

5.  Synthesis of Cyclooctenones  Using Intramolecular Hydroacylation.  Aloise, A.; Layton, M. E.; Shair, M. D. J. Am. Chem. Soc. 2000, 122, 12610-12611. pdf

4. Synthesis of (+)-CP-263,114.  Chen, C.; Layton, M. E.; Sheehan, S. M.; Shair, M. D. J. Am. Chem. Soc. 2000, 122, 7424-7425. pdf

3. A Highly Efficient and Convergent Reaction for the Synthesis of Bridgehead Enone-Containing Polycyclic Ring Systems.  Sheehan, S. M.; Lalic, G.; Chen, J.; Shair, M. D.  Angew. Chem. Int. Ed. Engl. 2000,  39, 2714-2715. pdf

2. Solid-Phase Biomimetic Synthesis of Carpanone-Like Molecules.  Lindsley, C; Chan, L.; Goess, B.; Joseph, R.; Shair, M. D. J. Am. Chem. Soc. 2000, 122, 422-423. pdf

1. Stereospecific Synthesis of the CP-263,114 Core Structure.  Chen, C.; Layton, M. E.; Shair, M. D. J. Am. Chem. Soc. 1998, 120, 10784-10785. pdf

Chemical Biology

5.  Self-Organization of the Mammalian Golgi Apparatus Revealed by a Small Molecule. Hannoush, R.; Goess, B. G.; Shair, M. D.; Kirchhausen, T. Submitted.

4.  Synthesis of a 10,000-membered Library of Molecules Resembling Carpanone and Discovery of Vesicular Traffic Inhibitors.  Goess, B.; Hannoush, R.; Chan, L.; Kirchhausen, T.; Shair, M. D. J. Am. Chem. Soc. 2006, 128, 5391-5403. pdf

3.  The Small Molecule Secramine Inhibits Cdc42-Dependent Functions in Cells and Cdc42 Activation In Vitro  Pelish, H. E.; Peterson, J. R.; Salvareeza, S. B.; Rodriquez-Boulan, E.; Nazef, N.; Annis, D. A.; Chen, J.-L.; Stamnes, M.; Feng, Y.; Shair, M. D.; Kirchhausen, T. Nature Chemical Biology 2006, 2, 39-46. pdf

2.  Use of Biomimetic Diversity-Oriented Synthesis to Discover Galanthamine-Like Molecules with Biological Properties Beyond Those of the Natural Product.  Pelish, H. E.; Westwood, N. J.; Feng, Y.; Kirchhausen, T.; Shair, M. D.  J. Am. Chem. Soc. 2001, 123, 6740-6741. pdf

1. A Closer View of an Oncoprotein-Tumor Suppressor Interaction.  Shair, M. D.  Chemistry and Biology, 1997, 4, 791. pdf